Chifukwa Chomwe Tifunikira Nicotinamide Riboside Chloride

Makampani ogulitsa zodzikongoletsera ndi bizinesi ya madola biliyoni, makamaka chifukwa anthu amapanga chidwi ndi momwe amawonekera. Ichi ndiye chinthu chofunikira kwambiri chofufuzira zokhudzana ndi zinthu zotsutsana ndi ukalamba ndi zinthu zomwe zapita patsogolo modabwitsa motere. Osonkhana onse apadziko lonse lapansi akumvetsetsa kuti pali ndalama zopangidwa kuchokera ku chikhumbo cha anthu kuti akhalebe chinyamata mpaka kalekale, motero, amakhala ndi magulu m'malo mwake, akumapereka masiku ndi masabata kuti apeze zosakaniza ndi zinthu zomwe zingalimbitse khungu. Nicotinamide Riboside kapena Niagen adapezeka chifukwa cha kafukufuku wosasunthika wazinthu zotsutsana ndi ukalamba. Ngakhale zinthu zambiri zotsutsana ndi ukalamba zimachepetsa zizindikiro za ukalamba kuchokera pakhungu, Niagen amachepetsa zizindikiritso za ukalamba mkati mwa thupi. Nicotinamide Riboside kapena Niagen ndi mawonekedwe a kristalo Nicotinamide Riboside mankhwala enaake ndipo kamodzi mkati mwa thupi, imasinthika kukhala NAD +, yomwe imayang'anira kukalamba wathanzi komanso ntchito zina zofunika kwambiri.

Munkhaniyi, tikamba za mbali zonse za pangani zodabwitsazi, kuphatikiza maubwino, zotsatira zoyipa ndi zotsatira zoyenera.

Kodi Nikotinamide Riboside Chloride ndi chiyani?

Nicotinamide Riboside Chloride kapena Niagen ndi mtundu wamakristali wa Nicotinamide Riboside, womwe ndi vitamini wa NAD + precursor. Ngakhale Nicotinamide Riboside akulemera 255.25 g / mol, Nicotinamide Riboside Chloride amalemera 290.70 g / mol ndi 100 mg ya Nicotinamide Riboside Chloride amapereka 88 mg ya Nicotinamide Riboside. NR imawoneka yotetezeka kugwiritsidwa ntchito muzakudya.

Ngakhale Nicotinamide Riboside ndi mtundu wa Vitamini B3, mawonekedwe ake osiyanasiyana amawapangitsa kukhala osiyana kwambiri ndi ena ambiri a gulu la Vitamini B3, monga nicotinamide ndi niacin. Ngakhale Niacin amachititsa kuti khungu lizituluka poyambitsa GPR109A G-protein coupept receptor, Nicotinamide Riboside sachitapo kanthu ndi cholandilira ichi motero, samachititsanso kuti khungu liziziririka, ngakhale mutamwa mankhwala okwanira 2000 mg patsiku. Kupitilira apo, kuyesa komwe kunachitika pa mbewa kudavumbulutsa kuti Nicotinamide Riboside ndiye NAD + wotsogola yemwe adatsogolera kuyimba kwambiri ku Nicotinamide Adenine Dinucleotide kapena NAD + mkati mwa thupi.

Nicotinamide Riboside imachitika mwachilengedwe mu chakudya chamunthu ndipo kamodzi mkati mwa thupi, imasinthika kukhala NAD +, yomwe thupi limafunikira ntchito zosiyanasiyana. Mwachitsanzo, kafukufuku wasayansi watsimikizira kuti Nicotinamide Riboside Chloride kapena NAD + yoperekedwa ndi NR imawongolera ntchito ya mitochondrial komanso kumva kwa insulin poyambitsa banja la sirtuin la ma enzymes, omwe amachititsa kayendedwe ka oxidative metabolism.

Pakadali pano, maphunziro asanu apangidwa kuti aphunzire za chitetezo ndi mphamvu ya Nicotinamide Riboside ndipo maphunziro onsewa apeza kuti poti chitetezo chimagwiritsidwa ntchito ndi anthu.

Nicotinamide Riboside mankhwala enaake ubwino

Tisanakambirane za maubwino a Nicotinamide Riboside Chloride, ndikofunikira kufotokozera kuti popeza Nicotinamide Riboside Chloride ndiye mchere womwe Nicotinamide Riboside amachokera, zabwino za Nicotinamide Riboside Chloride ndizofanana ndi zabwino za Nicotinamide Riboside.

Nicotinamide Riboside Chloride Amalimbikitsa Ukalamba Wathanzi

NAD + yothandizidwa ndi Nicotinamide Riboside Chloride mkati mwa thupi imayambitsa michere yapadera yolumikizidwa ndi ukalamba wathanzi. Imodzi mwa ma envulopu amenewa ndi ma sittuins, omwe ali ndi moyo wabwino komanso nyama. Kafukufuku wa sayansi adatsimikizira kuti ma sirtuins amasintha moyo wabwino komanso moyo wautali pochepetsa kutupa, kukulitsa phindu lomwe limakhudzana ndi kuletsa kwa calorie ndikukonzanso DNA yowonongeka. NAD + yothandizidwa ndi Nicotinamide Riboside Chloride imathandizanso ma polima a Poly omwe amadziwika kuti akonza zowonongeka za DNA. Kupitilira apo, maphunziro angapo asayansi adalumikiza ntchito yama polymerases ndi nthawi yowonjezera yamoyo.

Amachepetsa Mwayi Wopeza Matenda a Mtima

Ukalamba umathandizanso kuti munthu akhale ndi matenda amtima. Anthu akamakalamba, mitsempha yamagazi yawo imayamba kukhala yokhazikika komanso yolimba, yomwe imayambitsa kuthamanga kwa magazi. Magazi akachuluka m'mitsempha ikachuluka, mtima umayenera kugwira ntchito molimbika kupopa magazi, omwe umayambitsa matenda osiyanasiyana amtima. NAD + yoperekedwa ndi Nicotinamide Riboside Chloride imabweza kusinthana kwakukalamba komwe kumachitika chifukwa cha mitsempha yamagazi. Pali umboni wokwanira wa asayansi wotsimikizira kuti Nicotinamide Adenine Dinucleotide kapena NAD + samangolepheretsa magazi kulowa m'magazi komanso limayendetsa kuthamanga kwa magazi a systolic.

Nicotinamide Riboside Chloride Amaperekanso Chitetezo ku Maselo a Ubongo

Nicotinamide Riboside amateteza maselo aubongo. Kafukufuku yemwe adachitika pa mbewa adawonetsa kuti NR-inachititsa kupanga NAD + imachulukitsa kupanga PGC-1 alpha mapuloteni mpaka 50%. PGC-1 alpha mapuloteni amathandiza kuteteza maselo aubongo ku kupsinjika kwa oxidative komanso kumathandizanso ntchito ya mitochondrial. Ndiye, kuti kumwa kwa NR mwa anthu kumateteza kumatenda obadwa nawo aubongo, monga a Alzheimer's ndi Parkinson. Kafukufuku wina adafufuza momwe zotsatira za NAD + zimakhudzira anthu omwe akudwala Parkinson. Kafukufukuyu adatsimikiza kuti NAD + idasintha magwiridwe antchito a maselo.

Ubwino Wina wa Nicotinamide Riboside Chloride

Kuphatikiza pazopindulitsa zomwe tafotokozazi, apa ndi zina zowonjezera zochepa zomwe zimagwirizanitsidwa ndi Nicotinamide Riboside Chloride.

  • NR imadziwika kuwonjezera mphamvu ya minofu, kugwira ntchito komanso kupirira chifukwa chake, kugwiritsidwa ntchito kwa NR kumalumikizidwa ndi magwiridwe antchito abwinoko.
  • Monga tafotokozera pamwambapa, kupanga NR kolimbikitsa NAD + kukonzanso DNA yowonongeka ndikutiteteza ku kupsinjika kwa oxidative. Izi zimachepetsa mwayi wokhala ndi khansa.
  • Kafukufuku adafufuza momwe Nikotinamide Riboside amakhudzira kagayidwe ka mbewa. Phunziroli lidatsimikiza kuti NR idakulitsa kagayidwe ka mbewa. Ngakhale umboni wofunikira wasayansi ukufunika pankhaniyi, asayansi ambiri amakhulupirira kuti Nikotinamide Riboside ingakhudzenso anthu motero, iyenera kukhala yothandiza pakuchepetsa thupi.

Nicotinamide Riboside mankhwala enaake

Mlingo wa Nicotinamide Riboside Chloride

Maphunziro asanu omwe adachitika pano adazindikira kuti Nicotinamide Riboside ndiyotetezeka kuti anthu agwiritse ntchito. Komabe, maphunziro awa akhazikitsa otetezeka Nicotinamide Riboside mankhwala enaake mlingo malire a anthu pakati pa 1,000 mpaka 2,000 mg patsiku. Komabe, ziyenera kukumbukiridwa kuti maphunziro onse omwe amasanthula chitetezo cha Nicotinamide Riboside anali ndi zitsanzo zazing'ono kwambiri motero, kafukufuku wambiri akufunika m'derali.

Cholinga choyambirira cha Nicotinamide Riboside Chloride kwenikweni ndikupereka thupi la Nicotinamide Riboside Chloride kapena Niagen. Niagen kapena NR nthawi zambiri amapezeka m'mitundu iwiri: mapiritsi ndi makapisozi. Opanga ambiri a Nicotinamide Riboside othandizira amaphatikiza NR ndi mankhwala ena, monga Pterostilbene. Mulimonsemo, kuti mukhale otetezeka, opanga ambiri othandizira amalimbikitsa kuti azisunga kudya kwa tsiku ndi tsiku kwa NR pakati pa 250 mpaka 300 mg patsiku.

Kodi Nikotinamide Riboside Chloride Otetezeka?

Kafukufuku angapo omwe apangidwa pakadali pano apeza mowa wa Nicotinamide Riboside mumtunda wa 1000 mpaka 2000 mg patsiku otetezeka kuti anthu azigwiritsa ntchito. Komabe, popeza kuti maphunziro ochulukirapo a konkire amafunikira m'derali, opanga a Nicotinamide Riboside amalimbikitsa kuti azisunga kudya kwa tsiku ndi tsiku kwa NR pansi pa 250-300 mg patsiku.

Ngakhale Nicotinamide Riboside kapena Nicotinamide Riboside Chloride amakhala otetezedwa, zimatha kubweretsa zotsatirapo zake ngati nseru, mutu, kudzimbidwa, kutopa ndi kutsekula m'mimba. Ngati mukukumana ndi chilichonse mwazizindikiro izi mukumwa mankhwala a NR, nthawi yomweyo funsani kwa dokotala. Kuphatikiza apo, popeza palibe umboni wokwanira wama Nikotinamide Riboside azimayi oyembekezera komanso oyamwitsa, gulu ili liyenera kupewa kugwiritsa ntchito mankhwala othandizira a Nicotinamide Riboside.

Nicotinamide Riboside mankhwala enaake zowonjezerazo

Ngati mukufuna masamba Nicotinamide Riboside mankhwala enaake kuwonjezera, timalimbikitsa Tru Niagen Nicotinamide Riboside supplement. Chowonjezera ichi chimagwiritsa ntchito NIAGEN, kampani yomwe ili ndi kampani ya NR yokopa. Kampani yopanga imangogwira zopangira zowonjezera za Nicotinamide Riboside ndipo chifukwa chake, munthu akhoza kutsimikizira kuti zowonjezera zomwe zimapangidwa ndi kampani ndizopamwamba kwambiri. Powonjezera a Tru Niagen Nicotinamide Riboside amabwera makapu osavuta kudya, omwe ndi osavuta kuwameza. Ogwiritsa ntchito amayenera kutenga kapisozi kamodzi patsiku.

Komabe, ngati mukufuna gluten, dzira, BPA, mtedza, mankhwala osungira komanso mkaka, tikukulimbikitsani kuyika ndalama zanu muzowonjezera za Thorne ResveraCel Nicotinamide Riboside. Zowonjezera izi zimaphatikiza NR ndi flavonoids. Pamodzi, ziwiri izi zimathandizira ntchito ya sirtuin. Chofunika koposa, Thorne ResveraCel imati imayesa mayendedwe anayi pakuwonjezera kulikonse ndipo, zowonjezera zamakampani ndizabwino kwambiri. Kuphatikiza apo, zowonjezerazi zimapangidwa m'malo opezeka ndi cGMP ku United States komanso malo opezeka ndi TGA ku Australia.

Nicotinamide Riboside mankhwala enaake

Komwe Mugule Nicotinamide Riboside mankhwala enaake Powder mu Bulk?

Kufunikira kwa mankhwala othandizira ku Nicotinamide Riboside kwachulukanso kwambiri pazaka zingapo zapitazi, makamaka chifukwa Nicotinamide Riboside ali ndi zabwino zambiri. Ngati mukufuna kusinthana ndi msika wothandizira wa Nicotinamide Riboside, chinthu choyamba muyenera kuchita ndikupeza kuti ndi wodalirika komanso wodalirika popanga zinthu zopangira. Koti kugula Nicotinamide Riboside mankhwala enaake ufa wambiri? Yankho ndi Cofttek.

Cofttek ndiwophatikiza zida zopangira zinthu zomwe zinayamba kukhalapo mu 2008 ndipo m'zaka khumi zokha, kampaniyo yakhazikitsa kukhalapo kwawo m'maiko angapo. Kupatula kupanga zinthu zodalirika, kampaniyo imalimbikitsidwanso pakupita patsogolo pantchito za biotechnology, tekinoloje ya mankhwala ndi kuyesa kwa mankhwala. Kampaniyi idadzipatsanso kafukufuku wowoneka bwino, yemwe amathandizira kuti asagulitse ena ogulitsa. The Nicotinamide Riboside Chloride ufa operekedwa ndi kampani amabwera m'magulu 25 kg ndipo akhoza kukhala odalirika pamkhalidwe wabwino. Kuphatikiza apo, kampaniyo ili ndi magulu abwino kwambiri ogulitsa ndi othandizira makasitomala omwe amasamalira zosowa zanu zonse ndi kufunsa mafunso munthawi yeniyeni. Izi, ngati mukufuna kugula Nicotinamide Riboside Chloride ufa wambiri, khulupirirani Cofttek yekhayo.

Zothandizira
  1. Conze, D., Brenner, C. & Kruger, CL Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) mu Clomical Closed of Clomical of Doubleom, Double-Blind, Clinical of Greater Healthy Overweight. Sci Rep9, 9772 (2019)
  2. Carlijn ME Remie, Kay HM Roumans, Michiel PB Moonen, Niels J Connell, Bas Haskes, Julian Mevenkamp, ​​Lucas Lindeboom, Vera HW de Wit, Tineke van de Weijer, Suzanne ABM Aarts, Esther Lutgens, Bauke V Schomaker, Hyung L Elfrink, Rubén Zapata-Pérez, Riekelt H Houtkooper, Johan Auwerx, Joris Hoeks, Vera B Schrauwen-Hinderling, Esther Phielix, Patrick Schrauwen, Nicotinamide riboside supplementation alters body body and mifupa minofu acetylcarnitine mozungulira anthu athanzi labwino, The American Journal of Clinical Nutrition, Vesi 112, Kutulutsa 2, Ogasiti 2020, masamba 413-426
  3. Elhassan, YS, Kluckova, K., Fletcher, RS, Schmidt, MS, Garten, A., Doig, CL, Cartwright, DM, Oakey, L., Burley, CV, Jenkinson, N., Wilson, M., Lucas , S., Akerman, Ine, Seabright, A., Lai, YC, Tennant, DA, Nightingale, P., Wallis, GA, Manolopoulos, KN, Brenner, C.,… Lavery, GG (2019). Nicotinamide Riboside Augions a Ages Human Skeletal Muscle NAD + Metabolome ndi Induces Transcripttomic ndi Anti-kutupa Signature. Malipoti a selo, 28(7), 1717-1728.e6.
  4. Nicotinamide Riboside Chloride ufa

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