J-147 (1146963-51-0)

Mwina 7, 2021

Cofttek ndiye wopanga ufa wabwino kwambiri wa J-147 ku China. Fakitale yathu ili ndi dongosolo lathunthu loyang'anira kupanga (ISO9001 & ISO14001), lomwe limatha kupanga 120kg pamwezi.

 


Chikhalidwe: Mu Kupanga Misa
Unit: 1kg / thumba, 25kg / Drum

J-147 (1146963-51-0) Szizindikiro

Name: J-147
CAS: 1146963-51-0
Chiyeretso 98%
Maselo chilinganizo: C18H17F3N2O2
Kulemera kwa Maselo: 350.341 g / mol
Melt Point: 177-178 ° C
Dzina la mankhwala: 2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide
Mafanowo: N- (2,4-Dimethylphenyl) -2,2,2-trifluoro-N '- [(E) - (3-methoxyphenyl) methylene] acetohydrazide
InChI Key: HYMZAYGFKNNHDN-SSDVNMTOSA-N
Theka lamoyo: 1.5 hrs mu plasma ndi 2.5 hrs muubongo
Kutupa: Soluble mpaka 100 mM ku DMSO ndi 100 mM mu ethano
Zosunga: 0 - 4 C kwakanthawi kochepa (masiku mpaka masabata), kapena -20 C kwakanthawi (miyezi)
ntchito: J-147 ufa ndi mankhwala atsopano oyeserera omwe akupangidwa ngati chithandizo cha matenda a Alzheimer's.
Maonekedwe: Zoyera za ufa wopanda-oyera

 

J-147 (1146963-51-0) Makina a NMR

J-147 (1146963-51-0)

Ngati mukufuna COA, MSDS, HNMR pagulu lililonse lazogulitsa ndi zina, chonde lemberani oyang'anira malonda.

 

Kodi J-147 (1146963-51-0) ndi chiyani?

J-147 ufa ndi mankhwala atsopano oyesera omwe akupangidwa ngati chithandizo chotheka cha matenda a Alzheimer's. Pakadali pano, mayeso omwe amachitidwa pa mbewa amawonetsa lonjezo zambiri. J147 yawonetsa zotsatira zakubwezeretsa zotsatira za dementia ndi Alzheimer's mu mitundu ya mbewa. J147 imatenga njira yosiyana poyerekeza ndi mankhwala ena angapo a Nootropics ndi Alzheimer's. J147 imayesa kuchotsa zolembedwa mu ubongo. Ofufuzawo adazindikira kuti J147 imatha kuthana ndi mavuto ena okalamba obwera, osati kuiwalika. Mankhwalawa atha kuthandiza kuteteza magazi kuti asatayike pang'ono, monga akuwonetsa poyesa mbewa zomwe zachitika pakadali pano. Mankhwalawa adayamba kupangidwa mchaka cha 2011. Kuyambira pamenepo, mayesero akhala akuchitika pa mbewa koma sitinawone mayesero ena azachipatala a anthu. Komabe, kafukufuku wina wofalitsidwa chaka chatha amapereka chithunzi chabwino cha momwe J147 imagwirira ntchito muubongo wa munthu. Malinga ndi pepalalo, mankhwalawa amamangiriza mapuloteni mitochondria. Maselo a Mitochondria nthawi zambiri amakhala ndi vuto lopanga mphamvu. Kuchita kwa J147 pa iwo kumakulitsa kusinthika kwa maselo. Kubadwanso kwatsopano ndikofunikira kuti kubwezeretsanso kukumbukira kukumbukira ndikukulitsa thanzi lathunthu.

 

J-147 (1146963-51-0) maubwino

Titha Kuthetsa Mavuto Obweretsa Ubongo

J147 yawonetsa lonjezano lochulukirapo pakuchepetsa mavuto omwe amabwera chifukwa cha vuto la ubongo la neurodegenerative monga Alzheimer's ndi ena. Pazoyesedwa zochitidwa pamiyeso ya mbewa mpaka pano, mankhwalawa awonetsa zotsatira zabwino pothana ndi mikhalidwe iyi.

J147 imagwira ntchito pothandizira maselo muubongo kuti asinthe, kuwapanga kukhala ocheperana komanso othandiza kuposa maselo akale. Komabe, ndikofunikira kuzindikira kuti palibe zoyeserera za anthu zomwe zidachitidwa pazotsatira za J147. Tikukhulupirira, izi zichitika posachedwa koma mankhwalawa akupezekabe kuti azigulitsidwa ngati ufa m'masitolo ogulitsa pa intaneti.

 

Amasintha Mitochondria Action ndi Kukhala Ndi Moyo Wautali

J147 imagwira ntchito yomanga mu mitochondria, maselo omwe ali ndi udindo wopanga mphamvu m'matupi athu. Kuchita kwa J147 kumathandiza kupewetsa kupsinjika kwa oxidative m'maselo a mitochondria, zomwe zimapangitsa kuti maselo azigwira ntchito bwino komanso azikhala ndi moyo wautali.

J147 imathandizanso kuchepetsa ma metabolites omwe ndi oopsa omwe angayambitse kuchuluka kwa maselo, momwe maselo amafa akamadzitukumula mopitirira muyeso. Izi zimapangitsa kuti maselo anu azikhala atsopano komanso athanzi kwakanthawi. M'malo mwake, njira zina zochitidwa pazinyama zomwe zidawonetsa kuti kuwongolera kwa J147 pa ntchentche yazipatso kwakhalitsa nthawi yawo yayitali pofika 9.5 mpaka 12.8%.

 

Zimasintha Chikumbutso

J147 yawonetsanso lonjezo lambiri pakati pa mitundu yoyesera mbewa pakukweza kukumbukira. Mankhwalawa adathandizanso kusintha zolakwika zazachilengedwe m'maphunziro akale a kafukufuku.

Ofufuzawo amakhulupirira kuti zotulukazi zimatha kubwerezedwanso mwa anthu. Palinso umboni wina wosonyeza kuti J147 ikhoza kufufuzidwa ngati chithandizo chomwe chingachitike kukumbukira kukumbukira kwa malo.

 

Kuteteza Neurons komanso Kuthandiza Bongo Kukula

J147 imakhalanso ndi ma neuroprotective omwe amaletsa zochita za oxidative mkati mwa maselo. Izi zimathandiza kuteteza ma neurons kuti asawonongeke. J147 ikhoza kukhalanso yoyambitsa kukula kwa ubongo. J147 imathandizanso kusintha kwa khungu la synaptic muubongo, kumabweretsa kukula.

 

J-147 (1146963-51-0) ntchito?

Kukulitsa Kuzindikira

Chowonjezera cha J-147 chimathandizira kukumbukira kwakanthawi ndi kukumbukira kwakanthawi. Mankhwalawa amasintha zolakwika pakati pa okalamba omwe ali ndi vuto lakuzindikira. J-147 yogulitsa imapezeka ngati chiwongola dzanja ndipo achinyamata akutenga kuti akalimbikitse kuphunzira. Kutenga mankhwala osokoneza bongo a J-147 kumathandizanso kukumbukira, kuwona, komanso kuwunikira kwamaganizidwe.

 

Kusamalira Matenda a Alzheimer's

J-147 amapindulitsa odwala omwe ali ndi Alzheimer's pochepetsa kuchepa kwa vutoli. Mwachitsanzo, kutenga chowonjezeracho kumachepetsa kuchepa kwa beta-amyloid (Aβ), komwe kumabweretsa kusokonezeka kwa chidziwitso. Kuphatikiza apo, J-147 curcumin imathandizira kuwonetsa ma neurotrophin kutsimikizira kupulumuka kwa mitsempha, chifukwa chake, kukumbukira kukumbukira ndi kuzindikira.

Odwala omwe ali ndi AD amakhala ndi zochepa zochepa za neurotrophic. Komabe, kutenga J-147 Alzheimer's supplement kumalimbikitsa NGF ndi BDNF. Ma neurotransmitters awa amathandizira kupanga kukumbukira, kuphunzira, ndi magwiridwe antchito.

 

J-147 (1146963-51-0) mlingo

Kafukufuku wosiyanasiyana wagwiritsa ntchito mitundu yosiyanasiyana ya mbewa, koma imodzi mwamafukufuku owunikiridwa bwino idapatsa mbewa 10 mg / kg yolemera thupi patsiku. Kafukufuku wina adagwiritsa ntchito Mlingo wa 1, 3 kapena 9 mg / kg, ndipo adapeza zotsatira zodalira mankhwala, ndimiyeso yayikulu ikugwira ntchito bwino.

Komabe, kumasulira izi pamlingo wamunthu kumafunikira kusintha kwa thupi. Malinga ndi njira yogwiritsira ntchito yomwe imagwiritsidwa ntchito kwambiri, mlingo wofanana ndi umunthu uyenera kufanana ndi muyeso wama mbewa wogawidwa ndi 12.3-kapena .81 mg pa kg ya kulemera thupi patsiku.

Ndiwo .36 mg wa J147 pa paundi ya kulemera thupi patsiku. Izi zitha kukhala 36 mg patsiku la munthu mapaundi zana, 54 mg wa munthu 150 mapaundi, kapena 72 mg wa 200 mapaundi munthu.

Komabe, maphunziro ena apeza zotsatira zabwino kuchokera kumlingo wochepa kwambiri, ndipo popeza J147 ikulimbana ndi ubongo, sizikudziwikiratu kuti mlingowo ukhoza kukula bwino kutengera kukula kwa thupi.

Mwakutero, manambalawa ayenera kuwonedwa ngati malire apamwamba, ndipo pali zifukwa zomveka zokhulupirira kuti 10 mpaka 20 mg tsiku liyenera kukhala lokwanira kukhala ndi zotsatira zina.

 

J-147 ufa Zogulitsa(Kumene Mungagule ufa wa J-147 wochuluka)

Kampani yathu imakhala ndiubwenzi wamtundu wautali ndi makasitomala athu chifukwa timayang'ana kwambiri ntchito yamakasitomala komanso kupereka zopambana. Ngati muli ndi chidwi ndi malonda athu, timasinthasintha makonda anu kuti agwirizane ndi zosowa zanu ndipo nthawi yathu yotsogoza mwachangu imatsimikizira kuti mudzalawa malonda athu nthawi. Timayang'ananso ntchito zowonjezera phindu. Tili ndi mafunso azithandizo ndi chidziwitso chothandizira bizinesi yanu.

Ndife akatswiri opanga ufa wa J-147 kwa zaka zingapo, timagulitsa zinthu ndi mtengo wampikisano, ndipo malonda athu ndiabwino kwambiri ndipo amayesedwa mosamalitsa, odziyimira pawokha kuti awonetsetse kuti ndiwotheka kugwiritsa ntchito padziko lonse lapansi.

 

Zothandizira

[1] "Kuyesera kwamankhwala omwe akuyang'ana matenda a Alzheimer's kumawonetsa kulimbana ndi ukalamba" (Press release) Salk Institute. 12 Novembala 2015. Inabwezeretsanso Novembala 13, 2015.

[2] Brian L. Wang (13 Novembala 2015). "Kuyesera kwa mankhwala osokoneza bongo komwe kumayang'ana matenda a Alzheimer kumawonetsa zotsatira zotsutsana ndi ukalamba poyesa nyama". sonkhanb.com. Inabwezeretsedwa Novembala 16, 2015.

[3] Solomon B (Okutobala 2008). "Filamentous bacteriophage ngati chida chatsopano chothandizira matenda a Alzheimer's". Zolemba Za Matenda a Alzheimer's. 15 (2): 193–8. MAFUNSO: PMID 18953108.