Wopanga Nicotinamide Riboside Chloride (NR) (23111-00-4) Wopanga - Cofttek

Nicotinamide Riboside Chloride (NR) (23111-00-4)

April 7, 2020

Nicotinamide riboside, yomwe imadziwikanso kuti NR ndi SRT647, ndi mtundu wa pyridine-nucleoside wa vitamini B3 womwe umagwira ntchito ngati wotsogola wa nicotinamide adenine dinucleotide kapena NAD +. NR imalepheretsa kusokonezeka kwa ma serered a dorsal mizu ganglion neurons kuyambira ndikuwatchinjiriza ku kutayidwa kwamakutu kwa makutu amoyo.


Chikhalidwe: Mu Kupanga Misa
Unit: 25kg / Drum

Kanotinamide Riboside Chloride (NR) (23111-00-4) kanema

Nicotinamide Riboside Chloride (NR) Szizindikiro

Name: Nicotinamide Riboside Chloride (NR)
CAS: 23111-00-4
Chiyeretso 98%
Makhalidwe a Maselo: C11H15ClN2O5
Kulemera kwa maselo: 290.7 g / mol
Melt Point: 115-125 ℃
Dzina la mankhwala: 3-carbamoyl-1-((3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride
Mafanowo: Nicotinamide riboside; SRT647; SRT-647; SRT 647; Nicotinamide Riboside Triflate, chisakanizo cha α / β
InChI Key: YABIFCKURFRPPO-FSDYPCQHSA-N
Theka lamoyo: hours 2.7
Kutupa: Soluble ku DMSO, Methanol, Madzi
Zosunga: 0 - 4 C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 C kwa nthawi yaitali (miyezi)
ntchito: Nicotinamide riboside amadziwika kuti ndi mtundu watsopano wa pyridine-nucleoside wa vitamini B₃ yemwe amagwira ntchito ngati prequor to nicotinamide adenine dinucleotide kapena NAD +.
Maonekedwe: Choyera kwa Pale Pale ufa

Kodi Nicotinamide Riboside Chloride (NR) CAS 23111-00-4?

Nicotinamide riboside, yomwe imadziwikanso kuti NR ndi SRT647, ndi mtundu wa pyridine-nucleoside wa vitamini B3 womwe umagwira ntchito ngati wotsogola wa nicotinamide adenine dinucleotide kapena NAD +. NR imalepheretsa kusokonezeka kwa ma serered a dorsal mizu ganglion neurons kuyambira ndikuwatchinjiriza ku kutayidwa kwamakutu kwa makutu amoyo. Nicotinamide riboside imalepheretsa minofu, neural ndi melanocyte tsinde cell senescence. Kuchulukanso kwa minyewa ya mbewa kumaonedwa pambuyo pothandizidwa ndi nicotinamide riboside, zomwe zikuwachititsa kuganiza kuti zitha kusintha kusintha kwa ziwalo monga chiwindi, impso, ndi mtima. Nicotinamide riboside amachepetsa shuga wamagazi ndi chiwindi chamafuta mu prediabetesic ndi mitundu yachiwiri ya matenda ashuga pamene akuletsa kukula kwa matenda osokoneza bongo a shuga. Chidziwitso: Nicotinamide Riboside chloride ndi osakaniza a α / β.

Phindu la Nicotinamide Riboside Chloride (NR) CAS 23111-00-4

Nicotinamide nucleoside ndizotsogola zam'mbuyo za nicotinamide adenine dinucleotide (NAD) ndipo zikuyimira gwero la vitamini B3. Kafukufuku waposachedwa awonetsa kuti kumwa kuchuluka kwa ma nicotinamide nucleosides omwe amapezeka mwachilengedwe mu zakudya kumatha kupereka zabwino zathanzi. Mwachitsanzo, nicotinamide nucleosides idakhudzidwa ndikuwonjezera minofu ya NAD ndende ndikuthandizira chidwi cha insulin komanso kuwonjezera ntchito ya sirtuin. Kutha kwake kukulitsa kupanga kwa NAD kumawonetsa kuti nicotinamide nucleosides imathandizanso kukhala ndi thanzi la mitochondrial, kuyambitsa ntchito ya mitochondrial, ndikuyambitsa kupanga mitochondria yatsopano. Kafukufuku wina wogwiritsa ntchito nicotinamide nucleosides mu mtundu wa matenda a Alzheimer's awonetsa kuti molekyuluyo imapezekanso mu ubongo ndipo imatha kupereka mitsempha yodutsitsa ubongo mwa kuyambitsa kapangidwe ka ubongo wa NAD.

Nicotinamide Riboside Chloride ingathenso Kuchepetsa Kunenepa: Kafukufuku wasonyeza kuti mukachulukitsa mphamvu kagayidwe kake, mutha kuchepetsa bwino kwambiri chakudya chamafuta kwambiri. Pofuna kuwunika nthito ya nicotinamide ya NR yolimbikitsa kuchepa thupi, ofufuzawo anayeza chiwindi mitochondrial ntchito zomwe zimagwirizana ndi caloric, ntchito, zopatsa mphamvu, kuloza m'chiuno, kupuma kwa metabolic, kuphatikizira thupi, kulolera shuga, kuzindikira kwa insulin magawo. Izi ndi njira yatsopano yochepetsera zolemetsa yatsopano mwa malabsorption, chidziwitso cha zolembera zothandizira kutsatira. Ofufuzawo akuti mbewa zodyetsa nicotinamide nicotinamide zowonjezera ndizotheka kwambiri kuchepetsa kulemera kwa mbewa zomwe sizinathandizire nicotinamide

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 Njira Zamachitidwe?

Ma nicotinamide Riboside Chloride (NR) ma nucleoside a nicotinamide adenine dinucleotide (NAD) ndikuyimira gwero la vitamini B3. Kafukufuku waposachedwa awonetsa kuti kumwa kuchuluka kwa ma nicotinamide nucleosides omwe amapezeka mwachilengedwe mu zakudya kumatha kupereka zabwino zathanzi. Mwachitsanzo, nicotinamide nucleosides idakhudzidwa ndikuwonjezera minofu ya NAD ndende ndikuthandizira chidwi cha insulin komanso kuwonjezera ntchito ya sirtuin. Kutha kwake kukulitsa kupanga kwa NAD kumawonetsa kuti nicotinamide nucleosides imathandizanso kukhala ndi thanzi la mitochondrial, kuyambitsa ntchito ya mitochondrial, ndikuyambitsa kupanga mitochondria yatsopano. Kafukufuku wina wogwiritsa ntchito nicotinamide nucleosides mu mtundu wa matenda a Alzheimer's awonetsa kuti molekyuluyo ndiwopezekanso muubongo ndipo imatha kupatsanso neuroprotection mwakuwonjezera kapangidwe ka ubongo wa NAD ..

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 ntchito

Kafukufuku wachitika kale kuti kuwonjezerapo nthiti ya nicotinamide sikungangokulitsa kuchuluka kwa ma NAD +, komanso kukulitsa kugwiritsa ntchito kwa NAD + mwa anthu, zomwe sizingatheke ndi mavitamini ena a B3.Studies awonetsa kuti kamodzi chikonga cha nicotinamide chikuwonekera mu khungu, thupi limasintha mofulumira kukhala NAD +. Izi NAD + zimapangitsa kuti njira yokhazikitsidwa ndi intracellular ya kupanga mphamvu ndi mitochondria

Nicotinamide Riboside Chloride imatha kupititsa patsogolo ntchito ya mitochondrial, yomwe imawonetsedwa kuti ikuwonjezera kufotokoza kwa mapuloteni amagetsi otsogolera mitochondrial, kumapangitsanso kutulutsa kwa mitochondrial membrane, ndikuwonjezera kuchuluka kwa kupuma kwa oxidative komanso milingo ya intracellular ATP. Izi zitha kutsatiridwa ndi kusinthasintha kwamphamvu kwa mitochondrial. Ntchito ya Mitochondrial imatsika tikamakalamba, ndipo ichi ndi chizindikiro cha kukalamba kwa maselo a tsinde omwe timapeza. NR ikhoza kupititsa patsogolo ntchito za mitochondria ndikuletsa senescence yama cell a tsinde.

Nicotinamide Riboside Chloride (NR) ufa Zogulitsa(Koti Mugule Nikotinamide Riboside Chloride (NR) ufa wambiri)

Kampani yathu imakhala ndiubwenzi wamtundu wautali ndi makasitomala athu chifukwa timayang'ana kwambiri ntchito yamakasitomala komanso kupereka zopambana. Ngati muli ndi chidwi ndi malonda athu, timasinthasintha makonda anu kuti agwirizane ndi zosowa zanu ndipo nthawi yathu yotsogoza mwachangu imatsimikizira kuti mudzalawa malonda athu nthawi. Timayang'ananso ntchito zowonjezera phindu. Tili ndi mafunso azithandizo ndi chidziwitso chothandizira bizinesi yanu.

Ndife othandizira othandizira ufa a Nicotinamide Riboside Chloride (NR) kwa zaka zingapo, timapereka zogulitsa ndi mtengo wampikisano, ndipo malonda athu ndi apamwamba kwambiri ndipo amayesedwa mosamala, kudziyimira pawokha kuti awonetsetse kuti ndi otetezeka padziko lonse lapansi.

Zothandizira

  • Chi Y, Sauve AA. Nicotinamide riboside, michere ya zakudya m'zakudya, ndi vitamini B3 yokhala ndi mphamvu zama metabolism ndi neuroprotection. Curr Opin Clin Nutr Metab Care. 2013 Nov; 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. Unikani. PubMed PMID: 24071780.
  • Bogan KL, Brenner C. Nicotinic acid, nicotinamide, ndi nicotinamide riboside: kuwunika kwa mavitamini a NAD + precursor muzakudya za anthu. Annu Rev Nutr. 2008; 28: 115-30. doi: 10.1146 / annurev.nutr.28.061807.155443. Unikani. PubMed PMID: 18429699.
  • Ghanta S, Grossmann RE, Brenner C. Mitochondrial protein acetylation ngati cell-intrinsic, chisinthiko choyendetsa chosungiramo mafuta: michere ndi metabolic logic of acetyl-lysine kusintha. Crit Rev Biochem Mol Biol. 2013 Nov-Dec; 48 (6): 561-74. doi: 10.3109 / 10409238.2013.838204. Unikani. PubMed PMID: 24050258; PubMed Central PMCID: PMC4113336.