NR ufa (23111-00-4)

April 7, 2020

Cofttek ndiye wopanga wabwino kwambiri wa Nicotinamide Riboside Chloride powder ku China. Fakitale yathu ili ndi dongosolo lathunthu loyang'anira kupanga (ISO9001 & ISO14001), lomwe limatha kupanga 2100kg pamwezi.

 


Chikhalidwe: Mu Kupanga Misa
Unit: 1kg / thumba, 25kg / Drum

 

Mavidiyo a NR powder (23111-00-4)

 

Nicotinamide Riboside mankhwala enaake (NR) Szizindikiro

Name: Nicotinamide Riboside mankhwala enaake (NR)
CAS: 23111-00-4
Chiyeretso 98%
Maselo chilinganizo: C11H15ClN2O5
Kulemera kwa Maselo: 290.7 g / mol
Melt Point: 115-125 ℃
Dzina la mankhwala: 3-carbamoyl-1-((3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride
Mafanowo: Nicotinamide riboside; SRT647; SRT-647; SRT 647; Nicotinamide Riboside Triflate, chisakanizo cha α / β
InChI Key: Gawo #: YABIFCKURFRPPO-FSDYPCQHSA-N
Theka lamoyo: hours 2.7
Kutupa: Soluble ku DMSO, Methanol, Madzi
Zosunga: 0 - 4 C kwakanthawi kochepa (masiku mpaka masabata), kapena -20 C kwakanthawi (miyezi)
ntchito: Nicotinamide riboside amadziwika kuti ndi mtundu watsopano wa pyridine-nucleoside wa vitamini B₃ yemwe amagwira ntchito ngati prequor to nicotinamide adenine dinucleotide kapena NAD +.
Maonekedwe: Choyera kwa Pale Pale ufa

 

Nicotinamide Riboside mankhwala enaake

Thupi lamunthu ndipangidwe kovuta kupangidwa ndimaselo, ziwalo, ndi ziwalo. Kugwira ntchito moyenera kwa maselo ndi ziwalo m'thupi kumayendetsedwa ndikuthandizidwa ndi mankhwala osiyanasiyana, michere, ndi michere. Zina mwa izi thupi limatha kudzipanga lokha, ndipo zina zimayenera kudyedwa. Chifukwa chake, michere iyi imakhala ngati zakudya ndi zowonjezera. Chimodzi mwazigawozi zomwe zingathandize kuchiritsa ndikuwongolera thupi chimatchedwa nicotinamide riboside chloride (NR). Zimathandizira kuwonjezera kuchuluka kwa nicotinamide adenine dinucleotide (NAD +) mthupi.

 

Kodi Nicotinamide Riboside Chloride imatani?

Nicotinamide Riboside Chloride, yotchedwanso NR, ndi pyridine nucleoside ya vitamini B3. Imagwira ntchito potsogola kwa nicotinamide adenine dinucleotide (NAD +). Amapezeka ngati ufa wonyezimira wachikasu. Ndi imodzi mwazomwe zimaphunziridwa bwino kwambiri za NAD + popeza ili ndi maubwino ambiri azaumoyo. 

NAD + yakhala ikudziwika kuti ndi imodzi mwazinthu zofunika kwambiri zomwe zimagwira ntchito pamankhwala osiyanasiyana a homeostasis mthupi. Itha kuthandizira kusunga thupi kukhala lathanzi, kukulitsa kutalika kwa nthawi yayitali yamaselo, kuthandizira kuchita zinthu zingapo zamagetsi ndikuthandizira kuchiza ma pathophysiologies osiyanasiyana mthupi. 

NR ufa wasonyeza kuchita bwino ngati chithandizo chokwera m'matenda osiyanasiyana. Mlingo waukulu, NR imatha kuthana ndi matenda amtima, matenda opatsirana pogonana, matenda amisempha, ndi zovuta zamagetsi. NR yawonetsedwanso kuti imachedwetsa ukalamba wa maselo ndikutalikitsa moyo wawo. Amapezeka muzakudya monga nsomba, nkhuku, mazira, mkaka, ndi chimanga. 

 

Kodi Nicotinamide Riboside Chloride imatani?

Kuti timvetsetse zomwe nicotinamide riboside chloride imachita, tiyenera kumvetsetsa nicotinamide adenine dinucleotide kapena NAD +. 

NAD + ndi coenzyme yofunika m'thupi la munthu. Imagwira ntchito pochita njira zosiyanasiyana zamagetsi. Kukhalapo kwake m'thupi ndikofunikira pochiza mitundu yambiri yamatenda. Zimathandizanso kutulutsa mphamvu zamaubongo, ma immune immune, ndi minofu.

Kuchuluka kwa NAD + komwe kumapezeka kuzakudya ndizochepa kwambiri. Izi sizikwanira kuti maselo ambiri amthupi agwiritse ntchito. Chifukwa chake kuti apange, thupi limadutsa m'njira zosiyanasiyana. Pali njira zitatu zazikuluzikulu zomwe NAD + imatha kupangidwira. Njira ya De novo kaphatikizidwe, njira ya Preiss Handler, ndi njira ya Salvage.  

Njira ya Salvage ndiyo njira yofala kwambiri yomwe NAD + imapangidwira mthupi. Panjira iyi, NAD + imakumana ndi kusintha kwa redox. Zimaphatikizapo kuchepetsedwa ndi ma elekitironi ofanana, omwe amasandulika mawonekedwe otchedwa nicotinamide adenine dinucleotide (NADH). Popeza kuwonjezerapo zakudya sikokwanira kusowa kwa thupi kwa NAD +, njira yopulumutsa imagwiritsa ntchito ndikugwiritsanso ntchito NAD + yomwe ilipo kale ndi mitundu yake yosiyanasiyana. 

 Chimodzi mwazinthu zazikulu zomwe NAD + imachita ndikuyambitsa ma sirtuin, gulu la michere 7, Sirt1 mpaka Sirt7. Mavitaminiwa ali ndi ntchito yolamulira ukalamba ndi kutalika kwa maselo. Sirtuins amachita zinthu zambiri zamagetsi, monga kutulutsa kwa insulin, kulimbikitsa ma lipids, komanso kuyankha pamavuto. Itha ngakhale kuwongolera kutalika kwa moyo. Sirtuins imayambitsidwa pamene milingo ya NAD + ikwera. 

NAD + ndi gawo limodzi la gulu la mapuloteni otchedwa poly ADP-ribose polymerase (PARP). Imayang'anira kukonza kwa DNA ndikukhazikika kwama genome ndipo itha kukhala ndi udindo wokhala ndi moyo wautali. 

Mulingo wa NAD + umachepa ndi ukalamba ndi matenda. Zina mwazifukwa zakuchepa kwake ndikutupa kwanthawi yayitali, kuwonjezeka kwa chitetezo cha mthupi, komanso kuchepa kwa ntchito ya nicotinamide phosphoribosyltransferase (NAMPT), zomwe zimapangitsa kuchepa kwa kupanga. Thupi la munthu likamakalamba, kuchuluka kwa kuwonongeka kwa DNA kumawonjezeka ndi mwayi wocheperako, kuyambitsa ukalamba ndi khansa. 

Pali njira zingapo zokulitsira milingo ya NAD + mthupi. Akudya zochepa ndikuwongolera kuchuluka kwama calories, kusala, komanso kuchita masewera olimbitsa thupi. Izi zitha kuthandizanso kuti thupi likhale lathanzi komanso logwira ntchito.

Njira zina zowonjezera NAD + zimaphatikizapo kugwiritsa ntchito tryptophan ndi niacin ndikumwa ma NAD + othandizira monga nicotinamide riboside chloride ndi nicotinamide mononucleotide. 

Nicotinamide riboside chloride ndizomwe zingayambitse magulu a NAD +. Komanso ndi gwero la Vitamini B3. Ndi chinthu chomwe chimagwira njira yopulumutsa ya NAD + yopanga. Imasandulika nicotinamide mononucleotide (NMN) mothandizidwa ndi enzyme NR kinase Nrk1. Kenako imasandulika kukhala NAD +. 

Pambuyo popereka NR, milingo ya NAD + imakulira m'thupi, yomwe imagawidwa m'malo osiyanasiyana. Imatha kuwoloka chotchinga magazi-ubongo, koma imasandulika nicotinamide yomwe imatumizidwa kuubongo ndi ziwalo zina komwe imapanga NAD +. 

Zambiri zokhudzana ndi mphamvu ya Nicotinamide Riboside chloride zimachokera ku kafukufuku wa zinyama. Kafukufuku wofufuza za anthu akadali ochepa ndipo amafunikira kwambiri.

 

Ubwino wa Nicotinamide Riboside Chloride

Pali maubwino angapo ogwiritsira ntchito Nicotinamide Riboside Chloride. Ali: 

 

Zotsatira za Matenda a Neuromuscular

Kutha kwa Nicotinamide riboside chloride kukulitsa NAD + kumatha kusintha magwiridwe antchito a mitochondria. Izi zitha kuthandiza pochiza mitochondrial myopathies [1]. NR ufa wawonetsedwanso kuti ndiwothandiza pakukonza magwiridwe antchito am'mitsempha yamagetsi.

 

Zotsatira zamatenda amtima

Mavuto aliwonse a NAD + metabolism amatha kuyambitsa mavuto ndi mtima komanso mitsempha yamagazi. Zimatha kuyambitsa mikhalidwe monga kulephera kwa mtima, kupanikizika kwambiri, myocardial infarction, etc. NR supplementation imatha kubweretsa kuchuluka kwa NAD + ndi nicotinamide adenine dinucleotide + hydrogen (NADH) yachibadwa ndikuyimitsa kukonzanso kosavomerezeka kwamatenda amtima [2]. Itha kusinthanso zovuta zakulephera kwa mtima. 

 

Zotsatira zamatenda a neurodegenerative

Matenda a Neurodegenerative nthawi zambiri amachitika ndi ukalamba. Amalumikizidwa ndi kupsinjika kwa oxidative komwe kumatha kuwononga DNA. Nthawi zambiri pamakhala zochitika zosazolowereka za mitochondria, kutsatira zina pambuyo pake zomwe ma cell sangakwanitse kugwira ntchito bwino. NAD + imachepetsa kuchuluka kwa thupi, zomwe zimapangitsa kuti mitochondria isagwire bwino ntchito. Izi zitha kuyambitsa matenda osiyanasiyana amanjenje. Ikhozanso kuwonjezera mwayi wamatenda a Alzheimer's. 

Nicotinamide Riboside chloride imachulukitsa kuchuluka kwa NAD + m'thupi, imachepetsa kupsinjika kwa okosijeni, komanso imatha kukonzanso DNA yowonongeka. Zimathandizanso pochiza matenda a Alzheimer mu mbewa [3]. Ikhozanso kuchepetsa kutupa kwa ubongo, ndikuthandizira kukonza kuzindikira ndi kukumbukira [4]. Itha kuchita izi pochepetsa kuchuluka kwa mapuloteni otsegulira amyloid-β ndikuletsa amyloidogenesis. 

NR ufa ukhoza kuletsanso kuchepa kwa ma axon mu mitundu yayitali yamatenda amisempha posintha kagayidwe ka NR mu axon [5]. Kutha kwa ma ganglion neurons ozungulira omwe samasunga ma cell aubweya amatha kuchitika pambuyo paziwopsezo za phokoso lalikulu. NR yawonetsa kuti ndiyothandiza popewa kutayika kwakumva komwe kumapangitsa kuti phokoso lisamve. Imachita izi pogwiritsa ntchito njira ya sirtuin kapena SIRT3 yomwe imachepetsa kuchepa kwa mitsempha [6].  

 

Zotsatira za odwala matenda ashuga

Nicotinamide ribonucleoside chloride yawonetsa kuti ndi yothandiza pochepetsa zizindikilo zamavuto amadzimadzi monga Type II diabetes [7]. Zasonyezedwa kuti zimapangitsa kulekerera kwa shuga, kuchepetsa kulemera ndi kuwononga chiwindi mu mbewa. Chifukwa chake zitha kukhala zothandiza pochiza anthu. 

 

Zotsatira za thanzi la chiwindi

Matenda a chiwindi monga matenda a chiwindi osakhala mowa amawonetsedwa kuti amachititsa kuchepa kwa NAD +. Chifukwa chake, kuwonjezera ndi ufa wa NR kumatha kuthandiza kuchira bwino munthawi izi [8]. 

 

Zokhudza Ukalamba 

NAD + yapezeka kuti yachepetsa ukalamba wamaselo ndikuwatsitsimutsa. Zapezeka kuti zikuthandizira magwiridwe antchito am'magazi omwe amathandizanso kuchepetsa ukalamba [9]. 

 

Ubwino wa Nicotinamide Riboside Chloride Pazinthu Zina za NAD + Precursors

NR ili ndi bioavailability yabwinoko ndipo ndi yotetezeka kuyigwiritsa ntchito poyerekeza ndi ena omwe adatsogola. Zawonetsedwa kuti zikuwonjezera kuchuluka kwa NAD + kwambiri pakamwa pakamwa mu mbewa komanso zimapatsa NAD + yambiri minofu poyerekeza ndi ena oyamba. Itha kulamuliranso milingo yamagazi yamagazi ndikuwonjezera kuchuluka kwa NAD + mumtima [10]. 

 

Zotsatira zoyipa za Nicotinamide Riboside Chloride

Kudya pakamwa pa nicotinamide riboside chloride pamlingo wochepa kumakhala kotetezeka. Zitha kuphatikizira zovuta zina monga

  • nseru
  • Kutseka 
  • Edema
  • Kuyabwa
  • kutopa
  • litsipa
  • kutsekula
  • Zimakhumudwa m'mimba
  • Kudzikuza
  • kusanza

 

Momwe Mungagule Nicotinamide Riboside Chloride?

Ngati mukufuna kugula ufa wa NR, ndibwino kuti mulumikizane ndi fakitole wopanga wa Nicotinamide Riboside Chloride. Zimatsimikizira kuti zida zabwino kwambiri zimagwiritsidwa ntchito popanga, moyang'aniridwa ndi akatswiri pantchito yofananayo. Izi zimapangidwa motsatira malangizo okhwima otetezera omwe amatsimikizira kuti malonda ake ndiabwino kwambiri, ndi potency yayikulu, komanso amapakidwa bwino. Malinga ndi zosowa za wogwiritsa ntchito, malamulowa amatha kusinthidwa kuti agwirizane ndi zomwe amakonda. 

Chogulitsacho chikapangidwa, chimafunika kusungidwa kutentha kozizira kwa 0 mpaka 4C kwakanthawi kochepa -20C kwakanthawi. Ndikuteteza kuti zisawonongeke kapena kuchitidwa ndi mankhwala ena m'chilengedwe.

 

Zothandizira

  • Chi Y, Sauve AA. Nicotinamide riboside, michere ya zakudya m'zakudya, ndi vitamini B3 yokhala ndi mphamvu zama metabolism ndi neuroprotection. Curr Opin Clin Nutr Metab Care. 2013 Nov; 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. Unikani. PubMed PMID: 24071780.
  • Bogan KL, Brenner C. Nicotinic acid, nicotinamide, ndi nicotinamide riboside: kuwunika kwa mavitamini a NAD + precursor muzakudya za anthu. Annu Rev Nutr. 2008; 28: 115-30. doi: 10.1146 / annurev.nutr.28.061807.155443. Unikani. PubMed PMID: 18429699.
  • Ghanta S, Grossmann RE, Brenner C. Mitochondrial protein acetylation ngati cell-intrinsic, chisinthiko choyendetsa chosungiramo mafuta: michere ndi metabolic logic of acetyl-lysine kusintha. Crit Rev Biochem Mol Biol. 2013 Nov-Dec; 48 (6): 561-74. doi: 10.3109 / 10409238.2013.838204. Unikani. PubMed PMID: 24050258; PubMed Central PMCID: PMC4113336.
  • Chilichonse Chimene Muyenera Kudziwa Zokhudza Nicotinamide Riboside Chloride