Palmitoylethanolamide (PEA) ufa

April 7, 2020

Cofttek ndiye wopanga ufa wabwino kwambiri wa Palmitoylethanolamide (PEA) ku China. Fakitale yathu ili ndi dongosolo lathunthu loyang'anira kupanga (ISO9001 & ISO14001), lomwe limatha kupanga 3200kg pamwezi.

 


Chikhalidwe: Mu Kupanga Misa
Unit: 1kg / thumba, 25kg / Drum

Palmitoylethanolamide (PEA) powder (544-31-0) kanema

 

Palmitoylethanolamide (PEA) ufa Szizindikiro

 

Name: Palmitoylethanolamide (Pea)
CAS: 544-31-0
Chiyeretso 98% Micronized PEA ; 98% ufa
Maselo chilinganizo: C18H37NO2
Kulemera kwa Maselo: 299.49 g / mol
Melt Point: 93 ku 98 ° C
Dzina la mankhwala: Hydroxyethylpalmitamide Palmidrol N-Palmitoylethanolamine Palmitylethanolamide
Mafanowo: Palmitoylethanolamide

Zamgululi

N- (2-Hydroxyethyl) hexadecanamide

N-palmitoylethanolamine

InChI Key: HXYVTAGFYLMHSO-UHFFFAOYSA-N
Theka lamoyo: hours 8
Kutupa: Soluble ku DMSO, Methanol, Madzi
Zosunga: 0 - 4 C kwakanthawi kochepa (masiku mpaka masabata), kapena -20 C kwakanthawi (miyezi)
ntchito: Palmitoylethanolamide (PEA) ndi am'banja la endocannabinoid, gulu la amide acid amide. PEA yatsimikiziridwa kuti ili ndi ntchito ya analgesic komanso yotsutsana ndi kutupa ndipo yakhala ikugwiritsidwa ntchito m'maphunziro angapo olamulidwa omwe amayang'aniridwa pakuwongolera kupweteka kwapakati pakati pa odwala achikulire omwe ali ndi zovuta zosiyanasiyana zamankhwala.
Maonekedwe: White powder

 

Palmitoylethanolamide (544-31-0) Makina a NMR

Palmitoylethanolamide (544-31-0) - NMR Spectrum

Ngati mukufuna COA, MSDS, HNMR pagulu lililonse lazogulitsa ndi zina, chonde lemberani oyang'anira malonda.

 

Palmitoylethanolamide ndi endogenic fatty acid amide yomwe imagwera pansi pa gulu la Nuclear Factor Agonists. Nthawi zambiri zimapezeka mu zakudya monga soya, mtedza wa lecithin, ndi thupi la munthu.

Palmitoylethanolamide idapezeka koyamba koyambirira kwa ma 1940. Asayansi adapeza koyamba kuti kugwiritsa ntchito dzira lazira la ufa kumalimbikitsa chitetezo chamthupi mwa ana ndikuchepetsa chiopsezo chokhala ndi rheumatic fever. Kafukufuku wowonjezera adatsimikiza kuti yolks dzira limakhala ndi chophatikiza chapadera, PEA. PEA imapezekanso mu zakudya zonse monga mtedza ndi soya, zomwe zimathandiza kupereka chitetezo champhamvu komanso thanzi.

Kuphatikiza pa kupezeka mu zakudya zina, PEA imapezekanso mthupi lathu mwachilengedwe. Mankhwalawa amapangidwa mthupi lathu ndimaselo athu ambiri ngati gawo limodzi lamankhwala oteteza thupi kumatenda. PEA imapangidwa mwapadera ndi thupi lathu chifukwa cha kutupa. Amadziwika kuti amathetsa zopweteka zathu m'thupi poteteza chitetezo chathu cha mthupi kuti chisachite mopitilira muyeso ndipo zimalimbikitsa chitetezo chamthupi komanso chotupa mthupi.

Palmitoylethanolamide powder amagwiritsidwa ntchito kwambiri ngati mankhwala opweteka, fibromyalgia, kupweteka kwa m'mitsempha, multiple sclerosis, carpal tunnel syndrome, ndi zina zambiri.

 

Palmitoylethanolamide ndi Banja la Cannabinoid

Palmitoylethanolamide sikuti imachokera ku khansa koma imatha kuonedwa ngati gawo la banja la cannabinoid. PEA imagwiranso ntchito chimodzimodzi ndi CBD (cannabidiol), yomwe ndi imodzi mwazomwe zimayambitsa khansa koma ilibe zovuta zamaganizidwe. Zogulitsa za CBD ndizotchuka masiku ano ndipo zikupezeka pafupifupi chilichonse kuyambira mafuta mpaka mafuta, ndi zakudya. Zogulitsa za CBD zimagwiritsidwanso ntchito pazinthu zambiri zathanzi, kuphatikizapo misala, mitsempha, komanso thanzi limodzi.

PEA ilinso cannabinoid, koma imawunikidwa ngati Mapetocannabinoid momwe amapangidwira m'thupi. Komabe, ndizosiyana ndi cannabidiol ndi tetrahydrocannabinol chifukwa thupi silimapanga mankhwalawa mwachilengedwe.

 

Njira yogwira ntchito

Palmitoylethanolamide imayambitsa mafuta omwe amawotcha mafuta, opatsa mphamvu, komanso odana ndi zotupa a PPAR. Pamene mapuloteni ofunikirawa atsegulidwa, PEA imayimitsa zochita za majini zomwe zimatha kulimbikitsa kutupa ndikuchepetsa kupanga zinthu zingapo zotupa. PEA imachepetsanso zochitika za jini FAAH zomwe zimawononga zachilengedwe cannabinoid anandamide ndikulitsa kuchuluka kwa anandamide mthupi. Anandamide imathandizira kuchepetsa ululu wanu, kukhazika mtima pansi, komanso kulimbikitsa kupumula mthupi lanu.

PEA imadziwikanso kuti imamangiriza kumaselo amthupi ndikuchepetsa kupweteka ndi kutupa. Lili ndi asidi wa palmitic m'mapangidwe ake, omwe amathandiza thupi kupanga Palmitoylethanolamide mthupi.

Malinga ndi asayansi ena, kungowonjezera kudya kwa palmitic acid sikungakhudze kupanga kwa PEA. Izi ndichifukwa choti thupi lanu limangogwiritsa ntchito PEA mthupi lanu pokhapokha likafunikira kuchiritsa kutupa kapena kupweteka kwanu. Izi zimapangitsa kuchuluka kwa PEA mthupi mosiyanasiyana tsiku lonse.

Njira yabwino yopezera phindu la PEA ndikudya zakudya zopatsa thanzi za PEA kapena zowonjezera.

 

Palmitoylethanolamide powder mapindu ndi ntchito

PEA yatsimikiziridwa kuti ili ndi zothetsa ululu komanso zotsutsana ndi zotupa ndipo yagwiritsidwa ntchito pochiza ululu wosaneneka pakati pa achikulire omwe ali ndi zovuta zingapo zamankhwala. Mwachitsanzo, imatha kupereka chithandizo chothandiza ngati chithandizo chothandizira kupweteka kwa m'mbuyo kwa odwala okalamba kapena itha kugwiritsidwa ntchito payokha pakuwongolera zopweteka kwa odwala modwala m'malo mwa analgesics achikhalidwe omwe ali pachiwopsezo chachikulu chazovuta.

Zotsatira zolonjeza zawonetsedwa pochiza ma radiculopathies osachita opaleshoni okhala ndi michere yayikulu ya PEA ndi mankhwala ophatikizana ndi alpha-lipoic acid kuti achepetse matenda a prostatitis / matenda am'mimba am'mimba.

Pansipa pali zabwino zina za PEA:

 

· Mpumulo Wopweteka

Pali umboni wina wotsimikizira kuti PEA imatha kuchepetsa kupweteka kwambiri. PEA yafufuzidwa mwa anthu opitilira 6 zikwi ndi mayeso azachipatala 30 kuyambira ma 1070. Komabe, kafukufukuyu nthawi zambiri amalephera kusiyanitsa pakati pa ululu wam'mitsempha ya m'mimba ndi yosagwirizana ndi ubongo. Pulogalamu ya zabwino za Palmitoylethanolamide kupweteka kwa mitsempha sikumveka bwino chifukwa chazidziwitso zochepa zokwanira mpaka pano.

Lamulo lina linali lakuti ambiri mwa maphunzirowa analibe mphamvu yolamulira malowa ndipo kafukufuku wamakhalidwe abwino amafunikira kuti athe kudziwa momwe PEA imagwirira ntchito pothana ndi mitundu yosiyanasiyana ya zowawa.

Pakufufuza kwamaphunziro aumunthu a 12, zowonjezera za PEA zidawonetsa kuthandizira pakuchepetsa mphamvu ya ululu wam'mimba popanda vuto lililonse. Anthu 12 amenewo amapatsidwa mankhwala owonjezera a PEA okhala ndi mankhwala pakati pa 200 mpaka 1200 mg / tsiku kwa milungu yopitilira 3 mpaka 8. Zowonjezerazi zidatenga pafupifupi masabata awiri kuti zikwaniritse zowawa. Kutenga nthawi yayitali kumalimbikitsa zotsatira zake popanda kuyambitsa zovuta zilizonse.

Kafukufuku wina yemwe adachitika ndi 300 kapena 600 mg / tsiku la PEA adawonetsa kuchepa kwamphamvu kwa zowawa za sciatica poyesa kwakukulu kwa anthu opitilira 600. PEA imachepetsa ululu wopitilira 50% m'masabata atatu okha, omwe samakwaniritsidwa ndi othetsa ululu ambiri.

 

· Thanzi la ubongo ndi kusinthika

PEA imadziwikanso kuti ndi yopindulitsa pa matenda amanjenje ndi sitiroko. Chowonjezeracho chimawoneka kuti chikuthandizira kugwira ntchito kwa ubongo pothandiza ma cell aubongo kuti apulumuke ndikuchepetsa kutupa.

Pofufuza odwala 250 omwe adadwala sitiroko, kukhazikitsidwa kwa PEA ndi luteolin kunawonetsa zizindikiro zakupeza bwino. Imalengezedwanso kuti imathandizira thanzi labwino laubongo, luso lazidziwitso, komanso magwiridwe antchito aubongo tsiku ndi tsiku. Zotsatirazi zidawonekera patatha masiku 30 akuwonjezerapo ndipo patatha miyezi iwiri yowonjezerapo, kuwongolera kwina kunazindikirika.

Onse okhala ndi luteolin komanso okha, PEA idawoneka kuti iteteze matenda a Parkinson mu mbewa zikagwiritsidwa ntchito ndi luteolin. Amachepetsa kuwonongeka kwa ubongo poteteza ma dopamine neurons. Komabe, maphunziro ofunikira azachipatala amafunikira kuti atsimikizire izi.

Kafukufuku wina adawonetsa kuti PEA yokhala ndi luteolin idathandizira kukulitsa zinthu zama neurotrophic monga BDNF & NGF omwe ndi mapuloteni ang'onoang'ono othandiza kupanga ma cell atsopano aubongo. Zinathandizira kuti ubongo ukwanitse kusinthanso maselo ndi ziwalo zatsopano pambuyo povulaza msana kapena ubongo. Pamene PEA limodzi ndi luteolin idagwiritsidwa ntchito mu mbewa zimathandizira kuchiritsa kwa mitsempha mu mbewa ndi kuvulala kwa msana.

Chifukwa cha zochitika zachilengedwe za cannabinoids mu PEA, zotsatirazi zidawonetsa kupititsa patsogolo machitidwe a odwala, malingaliro awo. Idawonetsa kuchepa kwakuchepa kwa mbewa. Komabe, zotsatira zake zogwidwa sizikufufuzidwabe mwa anthu ndipo maphunziro ena amafunika kuti atsimikizire izi.

 

· Zotsatira pa Mtima

Matenda a mtima amabwera chifukwa chotseka mitsempha yopita kumtima. PEA imadziwika kuti ibwezeretse kuwonongeka kwamatenda amtima ndikuwonjezera magazi kutuluka pamtima zomwe zimathandiza kuchepetsa milandu ya matenda amtima. Kafukufuku wama mbewa adawonetsanso kutsika kwa milingo yotupa ya cytokine m'mitima.

Kugwiritsiridwa ntchito kwa PEA kunachepetsanso kuthamanga kwa magazi m'makoswe komanso kupewa kuwonongeka kwa impso pochepetsa zinthu zotupa. Pochepetsa mitsempha yamagazi, PEA inali yothandiza kutseka ma enzyme ndi zolandilira zomwe zimawonjezera kuthamanga kwa magazi.

 

· Zizindikiro zakukhumudwa

Kafukufuku waposachedwa, anthu a 58 omwe ali ndi vuto la kupsinjika adathandizidwa ndi PEA. Mlingo wa 1.2 gm patsiku amapatsidwa kwa odwala kwa milungu yopitilira 6. Izi zidapangitsa kuti zisinthe mwachangu pamachitidwe komanso zizindikiritso zonse. PEA ikawonjezeredwa ku mankhwala ochepetsa nkhawa, citalopram, imachepetsa zipsinjo zakukhumudwa ndi 50% yokhazikika.

 

· Zizindikiro za chimfine

Kafukufuku wina adawonetsa PEA kukhala njira yothanirana ndi kachilombo ka fuluwenza kamene kamayambitsa chimfine. M'mafukufuku ena oyambirira a anthu opitilira 4 zikwi, PEA idatha kuwonetsa chitetezo chokwanira ndikuthandizira kuchepetsa zizindikilo ngati chimfine kwa odwala.

Pakafukufuku wina, asitikali achichepere 900 adapatsidwa pafupifupi 1,200 mg ya PEA yomwe inachepetsa nthawi yozizira ndikuchiritsa zizindikiritso monga zilonda zapakhosi, mphuno, malungo, ndi mutu.

 

· Kutupa kwa m'matumbo

Pomaliza PEA idagwiritsidwa ntchito bwino kutsitsimutsa zizindikiritso zamatenda opatsirana (IBS) mwa nyama. Zowonjezera za PEA poyesedwa mu mbewa zomwe zimakhala ndi zotupa m'matumbo, zimathandizira kuyendetsa matumbo ndikuletsa kuwonongeka kwa matumbo.

Kuwonongeka kwa m'matumbo kapena kutupa kumayambitsidwa ndi ulcerative colitis yomwe ingayambitse chiopsezo cha khansa. Kugwiritsiridwa ntchito kwa PEA kudayimitsa matumbo abwinobwino polimbikitsa kufalikira kwa khansa mu mbewa. PEA imachepetsa ma cytokines otupa komanso kukula kwa ma neutrophil ndi maselo amthupi omwe amalimbitsa zizindikiritso zamatumbo.

 

Palmitoylethanolamide chakudya

Ngakhale PEA ndi mafuta okhathamira, kuphatikiza mafuta ochulukirapo pazakudya zanu zitha kuvulaza kuposa zabwino. Kudya zakudya zokhala ndi mafuta ochulukirapo sikungapangitse kutulutsa kwa thupi lanu kwa PEA m'malo mwake kumakulitsa chiopsezo chanu chokhala ndi matenda osiyanasiyana opatsirana.

Zakudya monga zopangira soya, lecithin ya soya, mtedza, ndi nyemba ndi zina mwazinthu zabwino za PEA. Anthu omwe ali ndi chifuwa cha mtedza amayenera kudumpha chiponde ndikudya zakudya zina. Dzira yolk ndi gwero lina labwino ndipo lingathe kudyedwa ndi anthu omwe samazindikira mazira. Ogwiritsa ntchito angaganizirenso kutenga zowonjezera za PEA popeza ndizabwino komanso zotheka.

 

PEA imathandizira mlingo & chitetezo

Malinga ndi kafukufuku wamankhwala, osachepera 600 mg / tsiku angafunike kuti athetse ululu wamitsempha, ndipo kuchuluka kwa 1.2 g / tsiku kungagwiritsidwe ntchito kuthana ndi ululu wamitsempha ya shuga.

Kwa odwala matenda ashuga omwe ali ndi vuto la diso, kuchuluka kwa 1.8 g / tsiku kunali kothandiza kuchepetsa kuwonongeka kwa mitsempha ya diso.

Pofuna kuchiza chimfine, 1.2 g / tsiku la PEA ndiye muyeso woyenera.

Lankhulani ndi dokotala musanamwe mankhwala a PEA chifukwa PEA sinavomerezedwe ndi FDA kuti atenge milingo yayikulu.

Kugwiritsa ntchito ufa wa Palmitoylethanolamide kapena zowonjezerapo zazing'ono, zochepa zimadziwika kuti ndi zotetezeka. Komabe, maphunziro apamwamba kwambiri azachipatala amafunikira pakuwonjezera mlingo. Kuonjezera kwa PEA kwanthawi yayitali kumadziwikanso kukhala kotetezeka malinga ndi kafukufuku wina wazing'ono.

Opanga ena ochokera ku fakitale yopanga ya PEA amalimbikitsa kuti agawanitse kuchuluka kwathunthu m'magawo awiri ndikuwadya masana. Nthawi zina, ma mica a PEA, omwe m'mawu osavuta ndi abwino a palmitoylethanolamide powder, amadziwika kuti amalowa bwino m'thupi ndipo asayansi amawona mawonekedwe a ufa kukhala apamwamba kuposa mitundu ina.

 

Zotsatira zoyipa za PEA

Kumwa pakamwa pa palmitoylethanolamide nthawi zambiri kumawoneka kotetezeka kwa achikulire ambiri akagwiritsidwa ntchito kwa miyezi itatu. Mpaka pano, palibe zovuta zazikulu kapena kulumikizana ndi mankhwala osokoneza bongo komwe kwadziwika. Komabe, palibe zambiri zokwanira kunena kuti mankhwalawa akhoza kukhala otetezeka akagwiritsidwa ntchito kwa nthawi yopitilira miyezi itatu. Zotsatira zoyipa zimatha kuphatikizira m'mimba wokwiya, zomwe ndizosowa kwambiri.

Kuti zidziwike bwino, PEA siyinayambitse zovuta zina pamaphunziro ali pamwambapa koma ilibe maphunziro oyenera achitetezo. Komanso, palibe umboni wokwanira wowerengera kuchuluka kwa mphamvu ya PEA mwa odwala omwe amamva ululu uwu.

 

Mimba ndi ana

PEA nthawi zambiri imawerengedwa kuti ndiyabwino kugwiritsa ntchito achikulire ndipo kafukufuku wowerengeka awonetsanso zochepa zowopsa kwa ana. Koma maphunziro akulu amafunika kutsimikizira chitetezo cha PEA mwa ana. Chifukwa chosowa chidziwitso chokwanira chazachipatala, amayi apakati ndi oyamwitsa akuti atsatire chenjezo ndikufunsana ndi dokotala asanamwe mankhwala aliwonse a PEA.

 

Kutsiliza

PEA yachepetsa zovuta zingapo ndikumva kupweteka ndikukweza moyo wabwino. Maphunziro ake amathandizira chitetezo cha mafuta ndipo amalimbikitsidwa kugwiritsa ntchito PEA. Chowonjezeracho ndichothandiza kwambiri pama syndromes ophatikizika kuphatikiza matenda a carpal tunnel ndi ululu wa sciatic. Zowonjezera za PEA ndizosavuta kutenga ndipo zitha kuperekedwa pakamwa.

Kumbukirani kukaonana ndi dokotala musanatenge mankhwala aliwonse a PEA chifukwa kuchuluka kwa PEA kumatha kubweretsa zovuta zina. Ngakhale zovuta ndizochepa kwambiri ndipo sizowopsa, PEA sayenera kugwiritsidwa ntchito m'malo mwa mankhwala ovomerezeka. Komabe, maubwino omwe anafotokozedwa pamwambapa adachitika makamaka munyama ndi m'maselo. Umboni wokhazikika wazachipatala ukusowabe.

Kafukufuku wowonjezereka mwa anthu amafunika kudziwa zotsatira za PEA pamatumbo, mtima, ndi mbiri ya histamine.

 

Palmitoylethanolamide (PEA) ufa wogulitsa & Kumene mungagule ufa wa Palmitoylethanolamide (PEA) wochuluka

Kampani yathu imakhala ndiubwenzi wamtundu wautali ndi makasitomala athu chifukwa timayang'ana kwambiri ntchito yamakasitomala komanso kupereka zopambana. Ngati muli ndi chidwi ndi malonda athu, timasinthasintha makonda anu kuti agwirizane ndi zosowa zanu ndipo nthawi yathu yotsogoza mwachangu imatsimikizira kuti mudzalawa malonda athu nthawi. Timayang'ananso ntchito zowonjezera phindu. Tili ndi mafunso azithandizo ndi chidziwitso chothandizira bizinesi yanu.

Ndife othandizira a Palmitoylethanolamide (PEA) ufa kwa zaka zingapo, timapereka zogulitsa ndi mtengo wampikisano, ndipo malonda athu ndi apamwamba kwambiri ndipo amayesedwa mosamala, kudziyesa pawokha kuti awonetsetse kuti ndi otetezeka padziko lonse lapansi.

 

Zothandizira

  • Hansen HS. Palmitoylethanolamide ndi ena opanga ma ancamide. Ntchito yomwe imagwiridwa mu ubongo wamatenda. Expur Neurol. 2010; 224 (1): 48-55
  • Petrosino S, Iuvone T, Di Marzo V. N-Palmitoyl-ethanolamine: biochemistry ndi mwayi watsopano wowerengeka. Biochimie. 2010; 92 (6): 724-7
  • Cerrato S, Brazis P, della Valle MF, Miolo A, Puigdemont A. Zotsatira za Palmitoylethanolamide pa histamine yokhazikitsidwa ndi histamine, PGD2 ndi TNFα kumasulidwa kwa maselo olimbitsa thupi a canine. Vet Immunol Immunopathol. 2010; 133 (1): 9–15
  • Palmitoylethanolamide (PEA): Ubwino, Mlingo, Kugwiritsa Ntchito, Zowonjezera