N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6)

Mwina 8, 2021

Cofttek ndiye wopanga ufa wabwino kwambiri wa N-Acetyl-L-cysteine ​​ethyl ester (NACET) ku China. Fakitale yathu ili ndi dongosolo lathunthu loyang'anira kupanga (ISO9001 & ISO14001), lomwe limatha kupanga 300kg pamwezi.
 


Chikhalidwe: Mu Kupanga Misa
Unit: 1kg / thumba, 25kg / Drum

N-Acetyl-L-cysteine ​​ethyl ester (59587-09-6) Szizindikiro

Name: N-Acetyl-L-cysteine ​​ethyl ester (NACET)
CAS: 59587-09-6
Chiyeretso 98%
Maselo chilinganizo: C7H13NO3S
Kulemera kwa Maselo: 191.25 g / mol
Melt Point: 197 ku 202 ° C
Dzina la mankhwala: N-Acetyl-L-cysteine ​​ethyl ester

NACET (R) -ethyl 2-acetamido-3-mercaptopropanoate

Mafanowo: N-Acetylcysteine ​​ethylester; (R) -Methyl 2-acetaMido-3-Mercaptopropanoate; -Ethyl 2-acetamido-3-mercaptopropanoate; Ethyl (2R) -2-Acetamido-3-Sulfanyl-Propanoate; (2R) -2-Acetamido-3-Mercaptopropanoic Acid Ethyl Ester; (2R) -2-Acetamido-3-Mercapto-Propionic Acid Ethyl Ester
InChI Key: MSMRAGNKRYVTCX-LURJTMIESA-N
Theka lamoyo: N / A
Kutupa: Sungunulani m'madzi
Zosunga: 0 - 4 C kwakanthawi kochepa (masiku mpaka masabata), kapena -20 C kwakanthawi (miyezi)
ntchito: N-Acetyl-L-cysteine ​​ethyl ester ufa agwiritsidwe ntchito kukulitsa kukumbukira, kuyang'ana, kukhazikika, luntha komanso kusonkhezera.
Maonekedwe: Kutsekemera koyera

 

N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) Makina a NMR

N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) NMR sipekitiramu

Ngati mukufuna COA, MSDS, HNMR pagulu lililonse lazogulitsa ndi zina, chonde lemberani oyang'anira malonda.

 

Kodi N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) ndi chiyani?

N-Acetyl-L-cysteine ​​ethyl ester ufa ndiwachilengedwe kapena zinthu zomwe zingapangitse ubongo kugwira ntchito, kukonza magwiridwe antchito am'maganizo mwa anthu athanzi. Omwe amadziwika kuti Nootropics ndi mankhwala osokoneza bongo, atchuka m'gulu lamakono lopikisana ndipo amagwiritsidwa ntchito kwambiri kukulitsa kukumbukira, kuyang'ana, luso, luntha komanso chidwi.

 

N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) zabwino

Kukhazikitsidwa kwa gulu la carboxyl kuti lipange N-acetylcysteine ​​ethyl ester kumawonjezera lipophilicity ya NAC ndipo imathandizira kwambiri pharmacokinetics. NACET ili ndi bioavailability yayikulu kwambiri (pafupifupi 60%) kuposa NAC. NACET imalowa mwachangu m'maselo, kenako nkumata, ndikusintha kukhala NAC ndi Cysteine. NACET imapezeka m'maselo amitundu yosiyanasiyana, kuphatikiza ubongo chifukwa imatha kuwoloka chotchinga magazi ndi ubongo. NACET imaperekanso zoteteza ku antioxidant. NACET ikhoza kutengedwa pakamwa ndikuthandizira kuwonjezera glutathione. Imatha kudziunjikira m'mitsempha yamagazi yamunthu. NACET itha kukhalanso ngati yoteteza ku hydroperoxide-yomwe imayambitsa kuwonongeka kwa okosijeni. NACA ili ndi kupezeka kwa bioavailability kopambana kuposa NAC komanso molekyulu yopititsa patsogolo kupirira komanso kukhalamo kwa nthawi ya bioscaffolds ndi biomaterials.

 

Brain

N-Acetyl-L-cysteine ​​ethyl ester powder 59587-09-6, ndi zinthu zachilengedwe kapena zopanga zomwe zingalimbikitse kugwira ntchito kwa ubongo, kukonza magwiridwe antchito am'mutu. Omwe amadziwika kuti Nootropics ndi mankhwala osokoneza bongo, atchuka m'gulu lamakono lopikisana ndipo amagwiritsidwa ntchito kwambiri kukulitsa kukumbukira, kuyang'ana, luso, luntha komanso chidwi.

NACET imakulitsa kufalikira kwa hydrogen sulfide (H (2) S), potero kuyimira woyenera wabwino wogwiritsa ntchito pakamwa monga H (2) S, wokhala ndi zabwino zowonekera kuposa NAC.

Pambuyo pochiritsidwa pakamwa, NACET (koma osati NAC) idatha kukulitsa kwambiri kuchuluka kwa GSH kwamatenda ambiri amphongo (kuphatikiza ubongo), ndikuwateteza ku kuledzera kwa paracetamol.

 

Thanzi Labwino

Kafukufuku wamkulu akuwonetsa kuti kuwonjezerapo zakudya ndi antioxidant N-acetylcysteine ​​(NAC) imatha kuletsa kubwereza kwa ma RNA ndikuchepetsa kuopsa kwa matenda omwe amabwera.

Kusintha kwa NAC kumeneku kumalola chitetezo cham'magazi anu kuwonongeke kuwonongeka kwa okosijeni, ndikupangitsa chitetezo cha mthupi lanu kuteteza thupi lanu ku ziwopsezo za COVID-19 (Awa si upangiri wa zamankhwala). NAC yokha imakhala ndi kuchepa kwa m'kamwa chifukwa imasinthidwa mwachangu m'chiwindi isanafike kumatumba anu, makamaka mapapu epithelium omwe ali pachiwopsezo chachikulu cha kuwonongeka kwa okosijeni kwa COVID-19.

 

N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) ntchito?

Mayeso akuluakulu azachipatala omwe adachitika posachedwapa adalephera kutsimikizira zotsatira zoyenera za N-acetylcysteine ​​(NAC) popewa matenda okhudzana ndi oxidative. Izi zitha kukhala chifukwa cha kuchepa kwachilengedwe. Tidaganiza kuti kuphatikizidwa kwa gulu la carboxyl la NAC kuti lipange N-acetylcysteine ​​ethyl ester (NACET) kuonjezera kwambiri lipophilicity ya NAC, motero kukonzanso kwake ma pharmacokinetics. Mu ntchitoyi yomwe tili pano, timapereka lipoti la NacET, ma pharmacological ndi anti-oxidant omwe akuimira, makamaka poyerekeza mwachindunji ndi NgenET yake yatsopano. Tidapeza kuti NACET imalowa kwambiri m'makola pambuyo pakamwa pakamwa koma imafika mozama kwambiri mu plasma. Izi zimachitika chifukwa cha gawo lapadera la NACET: imalowa mwachangu m'maselo omwe amakodwa kuti asinthidwe kukhala NAC ndi cysteine. Pambuyo pamankhwala am'kamwa, NACET (koma osati NAC) idatha kuwonjezera kwambiri glutathione zomwe zimakhala ndi minofu yambiri yowunika, kuphatikiza bongo, komanso kuteteza ku kuledzera kwa paracetamol mu rat. NACET ilinso ndi gawo lapadera lodziunjikira mu erythrocyte yaumunthu komwe imakhala ngati yoteteza mwamphamvu ku kuwonongeka kwa hydroperoxide-ikiwaletsa kuwononga makupidwe a oxidative. Kafukufuku wathu akuwonetsa kuti kukhala wokhoza kulowa m'maselo ndikutulutsa NAC ndi cysteine, NACET imawonjezera kuzungulira kwa hydrogen sulfide (H (2) S), motero kuyimira munthu wabwino pakugwiritsa ntchito pakamwa ngati H (2) S, wopanga maubwino pa NAC. NACET ili ndi mwayi wolowa m'malo mwa NAC ngati mucolytic wothandizira, ngati paracetamol antidote komanso ngati antioxidant wokhudzana ndi GSH.

 

N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) ntchito

NACET (N-Acetylcysteine ​​ethyl ester) ndi lipophilic cell-permeable cysteine ​​yotengedwa ndi mawonekedwe achilendo a pharmacokinetic ndi mwayi wodabwitsa wa antioxidant. NACET imakhala ndi mkamwa kwambiri. Ndi wolimba antioxidant komanso wolemera wotsogola wa GSH, womwe umagwirizana ndi acid yake ya N-acetyl -L yaulere imasiyana ndi -cysteine ​​(NAC). NACET ndi ufa woyera pamawonekedwe otentha ndipo umasungunuka momasuka m'madzi ndi ma organic sol sol.

NAC imachokera ku cysteine. Kuyambira mu 1970s, yakhala ikugwiritsidwa ntchito pochiza odwala omwe ali ndi acetaminophen overdose ndi mitsempha, ndipo amamugulitsa ngati mankhwala komanso zakudya zopatsa thanzi. Poyerekeza ndi NAC, NACET imakhala ndi lipophilicity yapamwamba komanso imatha kuchita mankhwala. Ili ndi mwayi wogwirizira Nac ya pharmacological, ngati othandizira a mucolytic, antioxidant, othandizira a GSH, paracetamol antidote, ndipo osachepera Donor of gaseous transmitter H 2 S ndi othandizira oteteza UV.

Kuphatikiza apo, mphamvu ya nucleophilicity ndikuchepetsa mphamvu ya NACET yatsimikizidwanso m'maselo ofiira a anthu. Zapezeka kuti zimadziunjikira m'magazi ofiira amtundu wa anthu, motsutsana ndi kuwonongeka kwa oxidative chifukwa cha hydroperoxides. Chifukwa chake, kuthekera kwa NACET monga anti-nitrite-ikiwaletsa antioxidant ndikokulira kuposa kwa NAC methemoglobinemia ndi ma oxidant ena amphamvu. Kafukufuku mu makoswe apeza kuti NACET imakhudzidwa mwachangu kwambiri kuposa NAC pamene NACET imayang'aniridwa pakamwa. Imatha kulowa m'maselo ndikutulutsa NAC ndi cysteine, zomwe zimawonjezera hydrogen sulfide (H (2) S) potulutsa. Ndiwofunika kusankha pakamwa ngati wopanga H (2) S,

 

NACET ufa Zogulitsa(Kumene Mungagule ufa wa NACET wochuluka)

Kampani yathu imakhala ndiubwenzi wamtundu wautali ndi makasitomala athu chifukwa timayang'ana kwambiri ntchito yamakasitomala komanso kupereka zopambana. Ngati muli ndi chidwi ndi malonda athu, timasinthasintha makonda anu kuti agwirizane ndi zosowa zanu ndipo nthawi yathu yotsogoza mwachangu imatsimikizira kuti mudzalawa malonda athu nthawi. Timayang'ananso ntchito zowonjezera phindu. Tili ndi mafunso azithandizo ndi chidziwitso chothandizira bizinesi yanu.

Ndife akatswiri othandizira ufa wa NACET kwazaka zingapo, timapereka zinthu ndi mtengo wopikisana, ndipo malonda athu ndiabwino kwambiri ndipo amayesedwa mosamalitsa, odziyimira pawokha kuti awonetsetse kuti ndiwotheka kugwiritsa ntchito padziko lonse lapansi.

 

Zothandizira

[1] N-acetylcysteine ​​ethyl ester monga GSH chothandizira mu maselo akulu a endothelial a anthu: Kafukufuku wofanizira ndi mankhwala ena. 2018 Oct; 126: 202-209. doi: 10.1016 / j.freeradbiomed.2018.08.013. Epub 2018 Aug 14. PMID: 30114478.

[2] N-acetylcysteine ​​ethyl ester monga GSH chothandizira mu maselo akulu a endothelial a anthu: Kafukufuku wofanizira ndi mankhwala ena. 2018 Oct; 126: 202-209. doi: 10.1016 / j.freeradbiomed.2018.08.013. Epub 2018 Aug 14. PMID: 30114478.

[3] S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) ndi N-acetyl-L-cysteine ​​ethyl ester (NACET) -Cysteine ​​ofotokoza omwe akufuna kugwiritsa ntchito mankhwala osokoneza bongo omwe ali ndi mbiri yapadera yamagetsi yogwiritsa ntchito pakamwa monga NO, H2S ndi GSH ogulitsa ndi monga antioxidants: Zotsatira ndi kuwunikira. 2018 Feb; 8 (1): 1-9. (Adasankhidwa) onetsani: 10.1016 / j.jpha.2017.12.003. Epub 2017 Dec 13. Kubwereza. PMID: 29568662.