α-ketoglutaric (328-50-7) (71686-01-6) - Fakitale yopanga

α-ketoglutaric

Cofftek imatha kupanga misa ndikupereka Calcium 2-oxoglutarate ndi Alpha-Ketoglutaric Acid pansi pa cGMP.

Mbendera ya Cofttek

Gulani ufa wa α-ketoglutaric

Kodi Alpha-Ketoglutaric Acid (328-50-7) ndi chiyani?

Alpha-ketoglutaric acid ndi chinthu chachilengedwe chomwe chimapezeka mwachilengedwe mthupi la munthu. Alpha-ketoglutaric acid yomwe imapezekanso ngati chowonjezera pazakudya, imathandizira kwambiri pakuzungulira kwa Krebs (mndandanda wazomwe zimagwiritsidwa ntchito potulutsa mphamvu zosungidwa). Alpha-ketoglutaric acid supplements akuti amatipatsa maubwino osiyanasiyana azaumoyo, kuphatikiza masewera othamanga komanso kagayidwe kabwino ka kagayidwe.

Alpha-Ketoglutaric Acid (328-50-7) maubwino

Pomwe zikunenedwa, kafukufuku wowerengeka wakale adawonetsa phindu lomwe alpha-ketoglutaric acid supplementation. Izi ndi zomwe ena mwa kafukufuku wapano akuti:
DiseMatenda a Impso Osatha
Alpha-ketoglutaric acid wakhala akugwiritsidwa ntchito kuyambira kumapeto kwa zaka za m'ma 1990 kuti athandize kuthetsa ndi kuyamwa mapuloteni mwa anthu omwe ali ndi hemodialysis omwe amafunikira zakudya zochepa zamapuloteni. Umboni waposachedwa ukuwonetsa kuti zithanso kuchedwetsa kufunikira kwa dialysis mwa anthu omwe ali ndi matenda a impso (CKD)

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Magwero Odalirika

PubMed Central

Zosungidwa zolemekezeka kwambiri zochokera ku National Institutes of Health
Pitani ku gwero

Malinga ndi kafukufuku wa 2017 mu nyuzipepala ya PLoS One, ofufuza adazindikira ndikutsata anthu 1,483 omwe anali ndi CKD yapamwamba omwe adagwiritsa ntchito alpha-ketoglutaric acid supplement yotchedwa Ketosteril. Avereji ya nthawi yotsatila inali zaka 1.57.
Poyerekeza ndi gulu lofananira la anthu omwe sanatenge chowonjezeracho, omwe adatero sakanafunikira dialysis yanthawi yayitali. Zopindulitsa zimangowonjezera kwa omwe amamwa mapiritsi opitilira 5.5 patsiku, zomwe zikuwonetsa kuti zotsatira zake zimadalira mlingo.
Ngakhale zabwino zomwe zapeza, sizikudziwika kuti alpha-ketoglutaric acid idachita chiyani poyerekeza ndi zosakaniza zina zomwe zimagwira. Kafukufuku wowonjezereka akufunika.

Umoyo wa m'mimba
Alpha-ketoglutaric acid supplements amakhulupirira kuti ndi anticatabolic, kutanthauza kuti amachepetsa kapena amalepheretsa kapena catabolism (kuwonongeka kwa minofu). Mwa kutanthauzira, njira ya catabolic imatsutsana ndi njira ya anabolic (momwe zimapangidwira).
Kafukufuku wa 2012 mu Italian Journal of Animal Science adanenanso kuti alpha-ketoglutaric acid idalepheretsa kuwonongeka kwa matumbo mu makoswe a labu omwe amadyetsa zakudya zopanda mapuloteni kwa masiku 14. M'malo mowonongeka kwa chala-ngati villi m'matumbo-chotsatira choyembekezeredwa - makoswe odyetsedwa a alpha-ketoglutaric acid analibe kuwonongeka kowonekera poyerekeza ndi makoswe omwe sanali.
Kuphatikiza apo, makoswewa adapereka zowonjezerazo adatha kukhalabe ndikukula bwino ngakhale kusowa kwathunthu kwa mapuloteni. Mlingo wapamwamba umapereka zotsatira zabwinoko.
Zotsatirazi zikuwoneka kuti zimathandizira zotsatira za alpha-ketoglutaric acid anticatabolic. Kuphatikiza pakugwiritsa ntchito matenda a impso, alpha-ketoglutaric acid imatha kuthandizanso anthu omwe ali ndi vuto la matumbo am'mimba komanso matenda a malabsorption monga matenda a celiac. Kafukufuku wowonjezereka akufunika.

Kuchita Masewera
Mosiyana ndi zimenezi, zotsatira za anticatabolic za alpha-ketoglutaric acid zimawoneka ngati zochepa zikagwiritsidwa ntchito pofuna kukula kwa minofu ndi masewera olimbitsa thupi.
Malinga ndi kafukufuku wa 2012 mu Journal of the International Society of Sports Nutrition, alpha-ketoglutaric acid inalibe mphamvu yowoneka pa mphamvu ya minofu kapena kuchita masewera olimbitsa thupi mwa amuna a 16 omwe ali ndi ntchito yophunzitsa kukana.

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Magwero Odalirika

PubMed Central

Zosungidwa zolemekezeka kwambiri zochokera ku National Institutes of Health
Pitani ku gwero

Pa phunziroli, theka la amuna anapatsidwa 3,000-milligrams (mg) ya alpha-ketoglutaric acid, pamene theka lina linapatsidwa malo a placebo 45 maminiti asanayambe kuchita masewera olimbitsa thupi a bench ndi miyendo. Mlungu wotsatira, zowonjezera zinasinthidwa, ndipo theka lililonse limalandira mankhwala ena.
Kuchita masewera olimbitsa thupi kunkatengera kuchuluka kwa kuchuluka kwa zolimbitsa thupi (TLV) zolimbitsa thupi zomwe zidachitika motsatana ndi kugunda kwamtima kusanachitike komanso pambuyo pochita masewera olimbitsa thupi. Zomwe zotsatirazi zikuwonetsa ndikuti kusowa kwa mayankho a catabolic sikufanana ndi kuyankha kwa anabolic, makamaka pakati pa othamanga.

Alpha-Ketoglutaric Acid (328-50-7) amagwiritsa ntchito?

Pa opaleshoni ya mtima, alpha-ketoglutaric acid nthawi zina amaperekedwa kudzera m'mitsempha (mu mitsempha) kuti achepetse kuwonongeka kwa minofu ya mtima chifukwa cha kuchepa kwa magazi. Kuchita zimenezi kungathandizenso kuti magazi aziyenda mu impso pambuyo pa opaleshoniyo.
Kugwiritsa ntchito kwake ngati chowonjezera sikutsimikizika kwenikweni. Madokotala ena amakhulupirira kuti alpha-ketoglutaric acid imatha kuchiza kapena kupewa matenda osiyanasiyana, kuphatikiza:
  • Zoopsa
  • matenda aakulu impso
  • Hepatomegaly (chiwindi chokulitsidwa)
  • Matenda a m'mimba
  • Kutulutsa pakamwa
  • kufooka kwa mafupa
  • Tendinopathy
  • Matenda yisiti
Chifukwa cha gawo lake pakutulutsa mphamvu zosungidwa, alpha-ketoglutaric acid nthawi zambiri amagulitsidwa ngati chowonjezera pamasewera. Othandizira ena amanenanso kuti zowonjezera zowonjezera zowonjezera zimatha kuchepetsa ukalamba.

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Magwero Odalirika

PubMed Central

Zosungidwa zolemekezeka kwambiri zochokera ku National Institutes of Health
Pitani ku gwero

Monga momwe zimakhalira nthawi zambiri ndi zowonjezera zomwe zimati zimathandizira mikhalidwe yambiri yosagwirizana, umboni wochirikiza zonenazi ndi wofooka. Zina, monga zowonjezera za "anti-aging" (makamaka pa kafukufuku wa 2014 wokhudza nyongolotsi za nematode), malire osatheka.

Alpha-Ketoglutaric Acid (328-50-7) mlingo

Zowonjezera za alpha-ketoglutaric acid zimapezeka m'mapiritsi, kapisozi, ndi ufa ndipo zimatha kupezeka mosavuta pa intaneti kapena m'masitolo odziwa zambiri zazakudya.
Palibe malangizo onse ogwiritsira ntchito moyenera ma alpha-ketoglutaric acid. Zowonjezera zimagulitsidwa pamlingo woyambira 300 milligrams (mg) mpaka 1,000 mg wotengedwa kamodzi tsiku lililonse kapena popanda chakudya. Mlingo wofikira 3,000 mg wagwiritsidwa ntchito m'maphunziro popanda zotsatirapo zoyipa.

Alpha-Ketoglutaric Acid (328-50-7) zotsatira zoyipa zomwe zingachitike

Alpha-ketoglutaric acid imatengedwa kuti ndi yotetezeka komanso yolekerera. Kafukufuku wofufuza zotsatira za alpha-ketoglutaric acid adanenanso za zovuta zochepa pambuyo pa zaka zitatu zogwiritsidwa ntchito.
Monga chigawo chopangidwa kuchokera ku ma amino acid osafunikira, alpha-ketoglutaric acid sizinthu zomwe mungathe kuziwonjezera mosavuta. Kuchulukira kulikonse m'thupi kumatha kutulutsidwa mumkodzo kapena kuphwanyidwa ndikumangirira ma amino acid pazifukwa zina.

(4)↗

Magwero Odalirika

PubMed Central

Zosungidwa zolemekezeka kwambiri zochokera ku National Institutes of Health
Pitani ku gwero

Ndi zomwe zanenedwa, chitetezo cha alpha-ketoglutaric acid mwa amayi apakati, amayi oyamwitsa, ndi ana sichinakhazikitsidwe. Izi zimaphatikizapo ana omwe ali ndi vuto la kagayidwe kachakudya monga kuchepa kwa alpha-ketoglutarate dehydrogenase (momwe milingo ya alpha-ketoglutaric acid imakwezeka modabwitsa).

Alpha-Ketoglutaric Acid ufa wogulitsa (Kumene Mungagule Alpha-Ketoglutaric Acid ufa wochuluka)

Kampani yathu imakhala ndiubwenzi wamtundu wautali ndi makasitomala athu chifukwa timayang'ana kwambiri ntchito yamakasitomala komanso kupereka zopambana. Ngati muli ndi chidwi ndi malonda athu, timasinthasintha makonda anu kuti agwirizane ndi zosowa zanu ndipo nthawi yathu yotsogoza mwachangu imatsimikizira kuti mudzalawa malonda athu nthawi. Timayang'ananso ntchito zowonjezera phindu. Tili ndi mafunso azithandizo ndi chidziwitso chothandizira bizinesi yanu.
Ndife akatswiri operekera ufa wa Alpha-Ketoglutaric Acid kwa zaka zingapo, timapereka zinthu pamtengo wopikisana, ndipo malonda athu ndi apamwamba kwambiri ndipo amayesedwa mosamalitsa, odziyimira pawokha kuti atsimikizire kuti ndi otetezeka kuti amwe padziko lonse lapansi.

Tsamba:

  1. Abrahams JP, Leslie AG, Lutter R, Walker JE. Kapangidwe ka 2.8 Kusintha kwa F1-ATPase kuchokera ku mitima ya mitsempha ya mitochondria. Chilengedwe. 1994; 370: 621-628. onetsani: 10.1038 / 370621a0.
  2. Alpers DH. Glutamine: kodi deta imathandizira chifukwa cha kuwonjezera kwa glutamine mwa anthu? Gastroenterology. 2006; 130: S106-S116. onetsani: 10.1053 / j.gastro.2005.11.049.
  3. Ashkanazi J, Carpertier Y, Michelsen C. Minofu ndi plasma amino acid kutsatira kuvulala. Ann Surg. 1980; 192: 78-85. onetsani: 10.1097 / 00000658-198007000-00014.