α-ketoglutaric

Cofftek imatha kupanga misa ndikupereka Calcium 2-oxoglutarate ndi Alpha-Ketoglutaric Acid pansi pa cGMP.

Kodi Alpha-Ketoglutaric Acid (328-50-7) ndi chiyani?

Alpha-ketoglutaric acid ndi chinthu chachilengedwe chomwe chimapezeka mwachilengedwe mthupi la munthu. Alpha-ketoglutaric acid yomwe imapezekanso ngati chowonjezera pazakudya, imathandizira kwambiri pakuzungulira kwa Krebs (mndandanda wazomwe zimagwiritsidwa ntchito potulutsa mphamvu zosungidwa). Alpha-ketoglutaric acid supplements akuti amatipatsa maubwino osiyanasiyana azaumoyo, kuphatikiza masewera othamanga komanso kagayidwe kabwino ka kagayidwe.

Alpha-Ketoglutaric Acid (328-50-7) maubwino

Pomwe zikunenedwa, kafukufuku wowerengeka wakale adawonetsa phindu lomwe alpha-ketoglutaric acid supplementation. Izi ndi zomwe ena mwa kafukufuku wapano akuti:
DiseMatenda a Impso Osatha
Alpha-ketoglutaric acid yakhala ikugwiritsidwa ntchito kuyambira kumapeto kwa zaka za m'ma 1990 kuti zithandizire kuwononga ndi kuyamwa mapuloteni mwa anthu omwe ali ndi hemodialysis omwe amafunikira zakudya zochepa. Umboni waposachedwa ukusonyeza kuti amathanso kuchedwetsa kufunikira kwa dialysis mwa anthu omwe ali ndi matenda a impso otsogola (CKD). Malinga ndi kafukufuku wa 2017 mu magazini ya PLoS One, ofufuza adazindikira ndikutsatira anthu 1,483 omwe ali ndi CKD yapamwamba omwe amagwiritsa ntchito alpha-ketoglutaric acid supplement yotchedwa Ketosteril. Nthawi yotsatirayi inali zaka 1.57. Poyerekeza ndi anthu omwe sanatenge zowonjezerazo, omwe sanachite nawo dialysis yayitali. Zopindulitsa zimangoperekedwa kwa iwo omwe amamwa mapiritsi oposa 5.5 patsiku, kuwonetsa kuti zotsatira zake zimadalira mlingo. Ngakhale zili zabwino, sizikudziwika kuti alpha-ketoglutaric acid idagwira bwanji poyerekeza ndi zina zowonjezera zowonjezera. Kufufuzanso kwina kuli kofunika.

Umoyo wa m'mimba
Alpha-ketoglutaric acid supplements amakhulupirira kuti ndi anticatabolic, kutanthauza kuti imachedwetsa kapena kulepheretsa kapena catabolism (kuwonongeka kwa minofu). Mwakutanthauzira, njira yofananira ndi yosiyana ndi njira ya anabolic (momwe zimamangidwa ndi ziwalo). Kafukufuku wa 2012 mu Italian Journal of Animal Science adati alpha-ketoglutaric acid imalepheretsa matumbo kuwonongeka kwa makoswe omwe amadyetsa zakudya zopanda mapuloteni masiku 14. M'malo mowonongeka ndi villi ngati chala cha m'matumbo-zomwe zimayembekezereka-makoswe omwe amadyetsa alpha-ketoglutaric acid sankawonongeka poyerekeza ndi makoswe omwe sanali. Kuphatikiza apo, makoswe omwe amapereka zowonjezerazo adakwanitsa kukula bwino ngakhale kulibe mapuloteni. Mankhwala apamwamba amapatsidwa zotsatira zabwino. Zomwe zapezazi zikuwoneka kuti zikuthandizira zotsatira za anticatabolic za alpha-ketoglutaric acid. Kuphatikiza pa momwe amagwiritsidwira ntchito mu matenda a impso, alpha-ketoglutaric acid itha kuthandizanso anthu omwe ali ndi vuto la m'mimba toxemia ndi matenda a malabsorption monga matenda a leliac. Kufufuzanso kwina kuli kofunika.

Kuchita Masewera
Mosiyana ndi izi, zotsatira za anticatabolic za alpha-ketoglutaric acid zimawoneka ngati zikuchepa zikagwiritsidwa ntchito pofuna kukula kwa minofu ndi masewera othamanga. Malinga ndi kafukufuku wa 2012 mu Journal of the International Society of Sports Nutrition, alpha-ketoglutaric acid sinakhudze mphamvu yamphamvu yamphamvu kapena kupirira mwa amuna 16 omwe anali ndi ntchito yolimbikira yolimbitsa thupi. Pa kafukufukuyu, theka la amunawa adapatsidwa 3,000-milligrams (mg) ya alpha-ketoglutaric acid, pomwe theka linalo adapatsidwa placebo mphindi 45 asanachite makina osindikizira a benchi ndi kusindikiza kwa mwendo. Sabata yotsatira, zowonjezerazo zidapukutidwa, theka lililonse limapeza mankhwala ena. Kuchita masewera othamanga kutengera kuchuluka kwa katundu wokwanira (TLV) wazomwe amachita mothandizana ndi ziwonetsero za mtima zisanachitike komanso zitatha. Zomwe zapezazi zikuwonetsa kuti kulibe kuyankha kwamphamvu sizofanana ndi kuyankha kwa anabolic, makamaka pakati pa othamanga.

Alpha-Ketoglutaric Acid (328-50-7) amagwiritsa ntchito?

Pochita opaleshoni ya mtima, alpha-ketoglutaric acid nthawi zina amaperekedwa kudzera m'mitsempha (mumtsempha) kuti achepetse kuwonongeka kwa minofu yamtima chifukwa chakuchepetsa magazi. Kuchita izi kungathandizenso kuthamanga kwa magazi kupita ku impso kutsatira opaleshoni. Kugwiritsa ntchito kwake ngati chowonjezera sikutsimikizika kwenikweni. Madokotala ena amakhulupirira kuti alpha-ketoglutaric acid amatha kuchiza kapena kupewa matenda osiyanasiyana, kuphatikizapo:
  • Zoopsa
  • matenda aakulu impso
  • Hepatomegaly (chiwindi chokulitsidwa)
  • Matenda a m'mimba
  • Kutulutsa pakamwa
  • kufooka kwa mafupa
  • Tendinopathy
  • Matenda yisiti
Chifukwa cha ntchito yake yotulutsa mphamvu zosungidwa, alpha-ketoglutaric acid nthawi zambiri imagulitsidwa ngati chowonjezera pamasewera. Ena mwa iwo amalimbikitsa kuti zowonjezera zowonjezerazo zimatha kuchepetsa ukalamba. Monga momwe zimakhalira ndi ma supplements omwe amati amathandizira zinthu zingapo zosagwirizana, umboni wotsimikizira izi ndiwofooka. Zina, monga zowonjezera za "anti-aging" katundu (kutengera makamaka kafukufuku wa 2014 wokhudzana ndi nyongolotsi za nematode), malire pazosatheka.

Alpha-Ketoglutaric Acid (328-50-7) mlingo

Alpha-ketoglutaric acid zowonjezera zimapezeka piritsi, kapisozi, ndi mitundu ya ufa ndipo zimapezeka mosavuta pa intaneti kapena m'masitolo odziwika bwino pazakudya. Palibe malangizo apadziko lonse lapansi momwe angagwiritsire ntchito alpha-ketoglutaric acid. Zowonjezera nthawi zambiri zimagulitsidwa m'miyeso ya 300 milligrams (mg) mpaka 1,000 mg yomwe imamwedwa kamodzi tsiku lililonse popanda kapena chakudya. Mlingo wa 3,000 mg wagwiritsidwa ntchito m'maphunziro osakhala ndi zovuta.

Alpha-Ketoglutaric Acid (328-50-7) zotsatira zoyipa zomwe zingachitike

Alpha-ketoglutaric acid imawonedwa ngati yotetezeka komanso yololera bwino. Kafukufuku wofufuza za zotsatira za alpha-ketoglutaric acid adawonetsa zovuta zochepa atatha zaka zitatu akugwiritsa ntchito. Monga cholumikizira chopangidwa kuchokera ku ma amino acid osafunikira, alpha-ketoglutaric acid sichinthu chomwe mungathe kumwa mopitirira muyeso. Zowonjezera zilizonse mthupi zimatha kutulutsa mkodzo kapena kuthyoledwa mzimango zomangira amino acid pazinthu zina. Ndizoti, chitetezo cha alpha-ketoglutaric acid mwa amayi apakati, amayi oyamwitsa, ndi ana sichinakhazikitsidwe. Izi zimaphatikizapo ana omwe ali ndi vuto lodana ndi metabolism monga alpha-ketoglutarate dehydrogenase kusowa (komwe alpha-ketoglutaric acid amakhala okwera modabwitsa).

Alpha-Ketoglutaric Acid ufa wogulitsa (Kumene Mungagule Alpha-Ketoglutaric Acid ufa wochuluka)

Kampani yathu imakhala ndi ubale wautali ndi makasitomala athu chifukwa timayang'ana kwambiri kasitomala ndikupereka zinthu zabwino. Ngati muli ndi chidwi ndi malonda athu, timasinthasintha ndi kusintha kwa malamulo kuti agwirizane ndi zosowa zanu komanso nthawi yathu yotsogola posachedwa ikutsimikizirani kuti mudzalawa malonda athu munthawi yake. Timayang'ananso pazinthu zowonjezera phindu. Tilipo pa mafunso okhudzana ndi ntchito ndi chidziwitso chothandizira bizinesi yanu. Ndife akatswiri a Alpha-Ketoglutaric Acid powder ogulitsa kwa zaka zingapo, timagulitsa zinthu ndi mtengo wampikisano, ndipo malonda athu ndiabwino kwambiri ndipo amayesedwa mwamphamvu, odziyimira pawokha kuti awonetsetse kuti ndiwotheka kugwiritsa ntchito padziko lonse lapansi.

Tsamba:

  1. Abrahams JP, Leslie AG, Lutter R, Walker JE. Kapangidwe ka 2.8 Kusintha kwa F1-ATPase kuchokera ku mitima ya mitsempha ya mitochondria. Chilengedwe. 1994; 370: 621-628. onetsani: 10.1038 / 370621a0.
  2. Alpers DH. Glutamine: kodi deta imathandizira chifukwa cha kuwonjezera kwa glutamine mwa anthu? Gastroenterology. 2006; 130: S106-S116. onetsani: 10.1053 / j.gastro.2005.11.049.
  3. Ashkanazi J, Carpertier Y, Michelsen C. Minofu ndi plasma amino acid kutsatira kuvulala. Ann Surg. 1980; 192: 78-85. onetsani: 10.1097 / 00000658-198007000-00014.