Urolithin ufa

Cofftek imatha kupanga misa ndikupereka urolithin a, urolithin b ndi Methylurolithin A pansi pa cGMP.

Kodi Urolithins ndi chiyani?

Urolithins ndi zotumphukira kapena ma metabolites a zigawo za ellagic acid monga ellagitannins. Zida za mankhwalawa zimapukusidwa kuchokera ku zotengera za ellagic acid ndi gut microbiota.

Popeza zomera zam'mimba ndizofunikira kwambiri popanga ma urolithin, kuchuluka kwa ma urolithin omwe amapangidwa mthupi kumadalira mtundu wa zamoyo zomwe zimakhala, chofunikira kwambiri cha gulu la Clostridium leptum. Zimanenedwa kuti anthu omwe ali ndi microbiota olemera mwa mamembala a gululi amapanga ma urolithin ochulukirapo kuposa omwe ali ndi maluwa ena am'matumbo monga Bacteroides kapena Prevotella.

Urolithins amapangidwanso kuchokera ku punicalagin m'matumbo, chimodzimodzi ngati ellagitannins, kenako amatuluka mkodzo. Kuti muwone momwe urolithin amapangira mthupi, magawo awo amafunika kuyang'aniridwa mumkodzo wa munthu yemwe wamwa zakudya zokhala ndi ellagic acid kapena zowonjezera ma urolithin monga chopangira chawo. Urolithin, kamodzi m'magazi, imatha kupezeka ngati ma glucuronides.

Urolithins amapezeka mwachilengedwe mu zakudya zingapo, ngakhale kuti si mamolekyu onse a urolithins omwe amatha kutengedwa kuchokera ku chakudya. Zakudya zokhala ndi asidi ellagic zikagayidwa, zimadalira zomera zam'matumbo kuti ziwononge ellagitannins ndi punicalagin kupitilirabe m'matabolite apakatikati ndi zomalizira; mamolekyulu urolithin.

Mamolekyu awa posachedwa adatchuka ndipo akupitilizabe kukwera ngati zowonjezera zakudya zabwino chifukwa cha anti-chotupa, anti-kukalamba, anti-yotupa, komanso kupindulitsa kwa autophagy. Kuphatikiza apo, mamolekyulu enieni a urolithin amalumikizidwa ndimphamvu zamagetsi chifukwa zimakhudza thanzi la mitochondrial. Kupanga mphamvu m'thupi ndi njira yomwe imapezeka mu mitochondria, ndikuwongolera magwiridwe antchito a organelle iyi ndi imodzi mwazinthu zambiri za Urolithins.

Mamolekyulu Odziwika a Urolithin

Ma Urolithins amatanthauzira pamodzi ma molekyulu osiyanasiyana a m'banja la urolithin koma ali ndi mitundu yosiyanasiyana yamankhwala, mayina a IUPAC, kapangidwe ka mankhwala, ndi magwero. Kuphatikiza apo, mamolekyuluwa amagwiritsidwa ntchito mosiyanasiyana mthupi la munthu motero amafotokozedwa mosiyanasiyana mu mawonekedwe owonjezera.

Ma Urolithins, atafufuza mozama, amadziwika kuti amaphulika ndi mamolekyulu otsatirawa mthupi, ngakhale sizodziwika bwino za mamolekyulu aliwonse:

● Urolithin A (3,8-Dihydroxy Urolithin)
● Urolithin A glucuronide
● Urolithin B (3-Hydroxy Urolithin)
● Urolithin B glucuronide
● Urolithin D (3,4,8,9-Tetrahydroxy Urolithin)

Urolithin A ndi Urolithin B, omwe amadziwika kuti UroA ndi UroB motsatana, ndi ma metabolites odziwika bwino a Urolithins mthupi. Awa awiri nawonso ndi mamolekyulu omwe akugwiritsidwa ntchito pakadali pano ndikuwonjezera ufa.

Kamodzi m'magazi, Urolithin A amapezeka ngati Urolithin A glucuronide, ndipo Urolithin B imatha kupezeka ngati Urolithin B glucuronide. Chifukwa cha ichi, akukhulupirira kuti ali ndi zovuta zofananira ndi omwe adawatsogolera monga momwe kafukufuku wa vivo sanathere ndi ma urolithin. Kuperewera kwa maphunziro a vivo kumapangitsa kukhala kovuta kuwunika ngati UroA ndi UroB glucuronides ali ndi vuto lililonse losiyana ndi UroA ndi UroB iwowo.

Urolithin A ali ndi chochokera china chomwe chitha kupezeka m'magazi, chotchedwa Urolithin A sulphate. Zotulutsa zonsezi zimagwira ntchito yake m'magazi ndikuchotsedwa pamachitidwe kudzera mumkodzo.

Urolithin D ndi mamolekyulu ena ofunikira omwe amapangidwa ndi zomwe zimachitika m'matumbo microbiota, komabe, sizambiri zomwe zimadziwika pazotsatira zake komanso momwe angagwiritsire ntchito. Pakadali pano, sigwiritsidwa ntchito pazowonjezera zilizonse kapena m'malo mwa chakudya, mosiyana ndi anzawo, UroA ndi UroB. Kuphatikiza apo, zakudya za Urolithin D sizikudziwika.

Urolithin A Powder Information Package

Urolithin A sichipezeka mwachilengedwe kuchokera kuzakudya ndipo ndi gulu lamagulu omwe amadziwika kuti benzo-coumarins kapena dibenzo-α-pyrones. Amagwiritsidwanso ntchito kuchokera ku ellagitannins kupita ku Urolithin A 8-Methyl Ether asadasinthidwenso ku Urolithin A. Izi zimapezeka kumapeto kwa fakitale yathu yopanga Urolithin A powder. MethylUrolithin A ufa amapezekanso kuti mugule zochuluka ngati zingafunike.

Urolithin A sichipezeka m'magulu omwewo, ngakhale ndi magwiridwe omwewo am'mbuyomu, mwa anthu osiyanasiyana chifukwa zimadalira ntchito ya gut microbiota. U metabolism wa Urolithin A amakhulupirira kuti amafunika Gordonibacter urolithinfaciens ndi Gordonibacter pamelaeae koma anthu ena omwe ali ndi izi akuwonetsabe zochepa pakapangidwe kamolekyulu.

Urolithin A.

Nambala ya CAS1143-70-0
Chiyeretso98%
Dzina la IUPAC3,8-Dihydroxybenzo [c] chromen-6-imodzi
Mafananidwe3,8-dihydroxy-6H-dibenzo (b, d) pyran-6-m'modzi; 3,8-DIHYDRO DIBENZO- (B, D) PYRAN-6-ONE; 3, 8-Dihydroxy-6H-benzo [c] chromen-6-m'modzi; Castoreum pigment ine; Urolithin A; 6H-Dibenzo (B, D) pyran-6-one, 3,8-dihydroxy-; 3,8-dihydroxy-6H-dibenzopyran-6-imodzi); urolithin-A (UA; 3,8-dihydroxy-6H-dibenzo (b, d) pyran-6-imodzi
Molecular FormulaC13H8O4
Kulemera kwa maselo228.2
Melting Point> 300 ° C
InChI KeyKufotokozera: RIUPLDUFZCXCHM-UHFFFAOYSA-N
fomuolimba
MaonekedweKuwala Kwakuda ufa
Theka lamoyoOsadziwika
KutupaMafuta mu DMSO (3 mg / mL).
Ulili yosungirakoMasiku mpaka Masabata: M'chipinda chamdima, chouma pa 0 - 4 madigiri C Miyezi kufikira Zaka: Mu Freezer, kutali ndi zakumwa pa -20 madigiri C.
ntchitoZakudya zimagwiritsidwa ntchito ngati chakudya m'malo ndi zowonjezera

Phukusi la Urolithin B Powder

Urolithin B ndi gulu la phenolic lomwe lidayamba kupangidwa kuchokera ku Januware wa 2021. Litha kupezeka mwa kudya zakudya zingapo zomwe zimachokera ku ma ellagitannins omwe amatha kupangika ndi Urolithin B. Wapezeka kuti ndi wamphamvu mankhwala odana ndi ukalamba omwe mungagule mochuluka ngati Urolithin B ufa.

Katundu wosiyanasiyana wa ufa wa Urolithin B wopezeka ku kampani yathu yopanga amatchulidwa pansipa:

Nambala ya CAS1139-83-9
Chiyeretso98%
Dzina la IUPAC3-Hydroxy-6H-dibenzo [b, d] pyran-6-imodzi
MafananidweZOCHITIKA 226; Urolithin B; Akosi BBS-00008028; 3-hydroxy urolithin; 3-hydroxy-6-benzo [c] chromenone; 3-hydroxybenzo [c] chromen-6-m'modzi; 3-Hydroxy-benzo [c] chromen-6-m'modzi; 3-HYDROXY-6H-DIBENZO [B, D] PYRAN-6-ONE; 6H-Dibenzo (b, d) pyran-6-one, 3-hydroxy-; 3-Hydroxy-6H-benzo [c] chromen-6-m'modzi AldrichCPR
Molecular FormulaC13H8O3
Kulemera kwa maselo212.2 g / mol
Melting Point> 247 ° C
InChI KeyGawo #: WXUQMTRHPNOXBV-UHFFFAOYSA-N
fomuolimba
MaonekedweUfa wonyezimira wonyezimira
Theka lamoyoOsadziwika
KutupaSungunuka pa 5mg / mL mukatenthetsa, madzi owoneka bwino
Ulili yosungirako2-8 ° C
ntchitoAnti-oxidant ndi Pro-oxidant supplement ndi zochitika za estrogenic.


Kupatula ma molekyulu akulu awa a Urolithins omwe amapangidwa chifukwa chazomera zam'matumbo, pali mamolekyu angapo omwe amakhala apakatikati omwe amapangidwa pomwe kuwonongeka kwa omwe adalipo kale. Izi ndizophatikizapo:

● Urolithin M-5
● Urolithin M-6
● Urolithin M-7
● Urolithin C (3,8,9-Trihydroxy urolithin)
● Urolithin E (2,3,8,10-Tetrahydroxy urolithin)

Palibe zambiri zomwe zimadziwika pamagulu awa kuyambira pano, komabe, kafukufuku wowonjezera atha kupeza zabwino ndi kagwiritsidwe ntchito ka mamolekyulu a Urolithin.

Kodi Urolithins amagwira ntchito bwanji?

Ma Urolithins, monga mankhwala ena omwe amagwiritsidwa ntchito pama supplements, amakhudza ziwalo ndi machitidwe osiyanasiyana mthupi, kuti apange zotsatira zake zopindulitsa. Magwiridwe a Urolithins, onse A ndi B, atha kugawidwa m'magulu asanu ndi limodzi, ndipo nthambi iliyonse imatha kutulutsa maubwino angapo.

● Katundu wa Antioxidant
Phindu lalikulu lokhala ndi antioxidant limachepetsa kupsinjika kwa oxidative mthupi. Kupsyinjika kwa okosijeni kumatanthauza kupsinjika kwama cell ndi ziwalo m'thupi chifukwa chazovuta zamankhwala zomwe zimapanga mankhwala osakhazikika, omwe amadziwikanso kuti owonjezera ufulu. Izi zopanda pake zaulere zimatha kutengapo gawo pakuchita zinthu mosakhazikika mthupi, zomwe zimawononga ma cell ndi ma tishu.

Urolithins amaletsa kupsinjika kwa okosijeni kumeneku, komwe kumapangitsa kuletsa kuvulala kwama cell ndikuwonjezera mwayi wopulumuka kwamaselo. Zotsatirazi zimatheka chifukwa cha kuchepa kwa kapangidwe ka ma cell a Reactive Oxygen Species (iROS), omwe ndi mtundu wa zopitilira muyeso zaulere. Kuphatikiza apo, ma antioxidant a Urolithin A ndi Urolithin B amapezekanso pochepetsa mawu a NADPH oxidase subunit, omwe ndi ofunikira pakuchita kwamankhwala komwe kumabweretsa kupsinjika kwa oxidative.

Pofuna kupanga antioxidant katundu, Urolithins amachulukitsanso mawonekedwe a antioxidant heme oxygenase-1 kudzera pa Nrf2 / ARE yowunikira njira. Izi zimawathandiza sikuti zimangochepetsa mankhwala owopsa komanso zimawonjezera michere yabwino yomwe imalimbikitsa ma antioxidant.

Ma Urolithins, akapatsidwa mbewa zomwe zimawonongeka ndi ubongo wa LPS, amaletsa kuyambitsa ma microglial, kapena m'mawu osavuta, mabala ndi kutupa komwe kumawonjezera chiopsezo chakuwonongeka kwa ubongo kwamuyaya. Zotsatira za urolithins amakhulupirira kuti ndizophatikiza ma antioxidant katundu ndi anti-inflammatory properties.

● Katundu Wotupa Wotupa
Zinthu zotsutsana ndi zotupa za Urolithins ndi chimodzi mwazifukwa zazikulu zakutchuka kwake mdziko lowonjezera. Njira yomwe mankhwalawa, makamaka Urolithin A, Urolithin B, ndi mawonekedwe awo a glucuronides, ndiosiyana kwambiri ndipo amatulutsa zotsatira zosiyana.

Mphamvu yotsutsana ndi yotupa ya Urolithin A ndi Urolithin B ili ndi njira yofananira ndi Non-Steroidal Anti-inflammatory Drugs kapena NSAID monga Ibuprofen ndi Aspirin. Ma Urolithins amadziwika kuti amalepheretsa kupanga PGE2 ndikuwonetsa COX-2. Monga ma NSAID amaletsa kufotokozera COX 1 ndi COX 2, titha kunena kuti Urolithins ali ndi vuto losagwirizana ndi zotupa.

Mphamvu zotsutsana ndi zotupa za Urolithins zatsimikiziridwa kuti sizimangolimbana ndi kutupa mthupi komanso zimatha kusintha kuwonongeka kwa ziwalo chifukwa cha kutupa kwanthawi yayitali komwe kudapangitsa kuti ziwalo zilephereke. Kafukufuku waposachedwa wapangidwa pamitundu yazinyama, zidapezeka kuti kumwa kwa urolithin kumatha kuchepetsa nephrotoxicity yomwe imayambitsa mankhwala poletsa kufa kwa khungu la impso ndi kutupa.

Zinapezeka kuti urolithin A ufa, woperekedwa pakamwa, umalepheretsa njira yotupa limodzi ndi proapoptotic cascade, chifukwa chake, kuteteza ntchito ya impso. Katundu wa Urolithin A pamodzi ndi ma urolithin ena amaloza m'tsogolo momwe mankhwalawa angagwiritsidwe ntchito ngati mankhwala komanso momwe akugwiritsidwira ntchito ngati zowonjezera.

● Katundu Wotsutsana ndi Khansa
Ma Urolithins amakhulupirira kuti ndi anti-carcinogenic chifukwa chakutha kwawo kukhala ndi zovuta monga kumangidwa kwamaselo, aromatase inhibition, kupatsidwa ulemu kwa apoptosis, kuponderezana kwa chotupa, kupititsa patsogolo kwa autophagy, ndi senescence, malamulo olembera a oncogenes, ndi ma factor factor kukula. Zotsatirazi, ngati kulibe, zingayambitse kukula kwa maselo a khansa. Zinthu zoteteza ku Urolithins zatsimikiziridwa, makamaka kwa khansa ya prostate ndi khansa ya m'matumbo, pomwe ofufuza ambiri amalimbikitsa kugwiritsa ntchito Urolithins ngati mankhwala oletsa khansa ya prostate.

Kafukufuku yemwe adachitika mu 2018 adasanthula zotsatira za Urolithin panjira ya mTOR ndi cholinga chopeza chithandizo cha khansa ya kapamba. Khansa ya Pancreatic imalumikizidwa ndi miyezo yayikulu yakufa, koma kafukufuku waposachedwa akuwonetsa kuti Urolithin atha kungowonjezera kupulumuka komanso amaletsa kulumikizidwa kwa ma cell am'matumbo kumadera ena amthupi, zomwe zimapangitsa metastasis. Urolithin A adaphunziridwa makamaka ndipo zotsatira zake zidafanizidwa ndi zomwe zimapangidwa ndi regimen yovomerezeka. Zinatsimikiziridwa kuti Urolithin A adatulutsa zotsatira zabwino akagwiritsidwa ntchito kuthana ndi khansa ya kapamba, munthawi zonsezi; ikagwiritsidwa ntchito payekha kapena ndi njira yothandizirayi.

Ndikufufuza kwina, maubwino a Urothilins atha kukhalanso ndi chithandizo cha khansa ya kapamba.

● Katundu wa Antibacterial
Urolithins amadziwika chifukwa cha ma antibacterial properties ndipo amakhala ndi izi mwa kuletsa kulumikizana kwa tizilombo, osaloleza kuti ayende kapena kupatsira ma cell. Amakhulupiliranso kuti ali ndi zida zowononga mafangayi, ngakhale makina ake enieni sanadziwikebe.

Pali tizilombo toyambitsa matenda awiri omwe Urolithins ali ndi mphamvu zowononga kwambiri, zomwe zimapangitsa kuti thupi la munthu lizitetezedwa. Tizilombo toyambitsa matendawa ndi tizilombo toyambitsa matenda a malaria ndi Yersinia enterocolitica, ndipo zonsezi zimayambitsa matenda aakulu mwa anthu. Njira yomwe Urolithins ali nayo ma antibacterial katundu mosasamala kanthu kuti thupi ndilofanana.

● Katundu wa Anti Estrogenic ndi Estrogenic
Estrogen ndi mahomoni ofunikira m'thupi la mkazi, ndipo kutsika kwake kumalumikizidwa ndi zizindikilo monga kutsuka, kutentha, komanso kuchepa kwa mafupa. Popeza kufunikira kwa mahomoni, ndizomveka kuti cholowa m'malo chikufufuzidwa mwachangu. Komabe, mahomoni obwera kunja amakhala ndi zovuta zina zomwe zimapangitsa kugwiritsa ntchito kwawo kukhala kosafunikira.

Komabe, Urolithin A ndi Urolithin B ali ndi mawonekedwe ofanana ndi amkati a estrogen komanso kuyanjana kwa ma estrogen receptors mthupi. Urolithin A imagwirizana kwambiri, makamaka kwa alpha receptor poyerekeza ndi beta receptor. Ngakhale mankhwala onsewa ali ndi mawonekedwe ofanana ndi estrogen, ma urolithin ali ndi ma estrogenic komanso anti-estrogenic, mosiyana ndi amino estrogen.

Kuphatikizika kwa zotsatirazi za Urolithins kumawapangitsa kukhala njira yothandizila pamavuto ena omwe amabwera pamene estrogen yotchuka imaperekedwa kuti ithetse zovuta zakusowa kwa estrogen.

● Mapuloteni Glycation Inhibition
Mapuloteni glycation ndi njira yomwe molekyulu ya shuga imamangiriridwa ku protein. Izi zimawoneka ukalamba kapena ngati gawo la zovuta zina. Urolithins amaletsa kuwonjezera kwa shuga, motero kumayambitsa zotsatira za anti-glycation. Kuphatikiza apo, amaletsa mapangidwe apamwamba a glycation endproducts mapangidwe, omwe kudziunjikira kwake ndikofunikira pakukula kwa matenda ashuga.

Ubwino wa Urolithins

Ma Urolithins ali ndi njira zosiyanasiyana zopangira zopindulitsa zosiyanasiyana m'thupi la munthu. Urolithin A ufa ndi Urolithin B ufa umathandizira kupanga zowonjezera zomwe ndizodziwika chifukwa chazabwino zopangira zazikulu. Phindu lonse la mankhwalawa limathandizidwa ndi umboni wa sayansi, ndipo ngakhale kafukufuku wina akuchitidwa kuti athandizire kuwonjezera kwa Urolithins muupangiri wothandizira zovuta zingapo.

Ubwino wa mankhwalawa, kutengera njira zomwe tatchulazi, ndi izi:

● Katundu wa Antioxidant
Urolithins amachokera kuzakudya zambiri za ellagitannins zomwe zimadziwika kuti ndizolemera ma antioxidants. Chakudya chofala kwambiri cha ellagitannins ndi ellagic acid ndi makangaza, komanso ndi gwero lalikulu la ma antioxidants. Komabe, ndikofunikira kusiyanitsa ngati ma antioxidant omwe amapangira chakudya ndi ma urolithin ali ofanana kapena ngati wina ali ndi kuthekera kopitilira mnzake.

Kafukufuku woyambirira wa Urolithin A ndi Urolithin B adawonetsa kuti ma antioxidant amtunduwu anali ocheperako ndi 42 poyerekeza ndi chipatso chomwecho, motero kutanthauza kuti mankhwalawa sangapangire zowonjezera zowonjezera.

Komabe, kafukufuku waposachedwa wokhala ndi njira yosanthula yosiyana akuwonetsa kuti Urolithin A ndi B onse ndiwothandiza kwambiri ndipo ali ndi zida za antioxidant zomwe zingalimbane ndi zovuta zamavuto. Pomwe njira yofananira yomwe idagwiritsidwa ntchito pophunzira ma urolithin onse kuti muwone omwe ali amphamvu kwambiri, Urolithin A adadziwika. Zotsatira zake zidatulutsidwanso kafukufuku wofananira ndi Urolithin A akutsogolera potency, kachiwiri.

M'malo mwake, imodzi mwa kafukufukuyu idayang'ana pakuwunika ma antioxidant a mankhwalawa poyesa kuthana ndi kupsinjika kwa oxidative. Pachifukwa cha kafukufukuyu, ofufuza adayambitsa kupsinjika m'maselo amitsempha yamagazi ndipo atakumana ndi Urolithins, makamaka Urolithin B, adawona kuchepa kwakukulu kwa kupsinjika komanso kupulumuka kwamaselo amitsempha.

● Katundu Wotupa Wotupa
Mphamvu zotsutsana ndi zotupa za Urolithins zimabweretsa maubwino angapo, zonse zomwe zatsimikiziridwa mwasayansi.

1. Zotsatira za malungo
Mankhwala opangira mankhwala a malungo omwe amagwiritsidwa ntchito kwambiri kumadera ena akumidzi amaphatikizapo kugwiritsa ntchito Makangaza. Ofufuza amayesa kumvetsetsa zotsatira zabwino za mankhwalawa pochiza malungo pokhudzana ndi zotsatira za ma Urolithins opukusidwa m'matumbo kuchokera pamakangaza.

Kafukufuku adachitidwa kuti aphunzire momwe Urolithins amathandizira pochiza malungo powonetsa maselo a monocytic ku Urolithins. Kafukufukuyu anapeza kuti mankhwala amapangitsa kuti MMP-9 isatuluke, yomwe ndi metalloproteinase yofunikira pakukula ndi matenda a malungo. Kuletsa kwa kampaniyo kumalepheretsa malungo kukhala tizilombo toyambitsa matenda m'thupi, chifukwa chake amakhulupirira kuti ali ndi zotsatira za malungo.

Zotsatira za kafukufukuyu zikuwonetsanso kuti Urolithins amaletsa mRNA kufotokozera tizilombo toyambitsa matenda, zomwe zimapangitsa kuti tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda. Zotsatira za kafukufukuyu zikuwonetsa kuti zabwino zopangidwa ndi zokometsera zokometsera kuphatikiza makangaza zimadza chifukwa cha urolithin.

2. Zotsatira pa Maselo Endothelial
Matenda a atherosclerosis ndichizolowezi chomwe chimayambitsa matonzo amtima komanso infaracional myocardial. Zinthu ziwiri zomwe zimayambitsa kukula kwa atherosclerosis ndikumapeto kwa magwiridwe antchito komanso kutupa. Kafukufuku waposachedwa ayesa kutsimikizira kuti zotsutsana ndi zotupa za Urolithin zitha kupewetsa kutha kwa endothelial, chifukwa chake, kuyang'anira mapangidwe ndi atherosclerosis.

Urolithin A anapezeka ndi ofufuza kuti ali ndi njira yotsutsa-yotupa kwambiri pakati pa ma urolithin onse. Kafukufuku waposachedwa amayang'ana kwambiri ma cell a endothelial omwe amaphatikizidwa ndi LDL ya oxidized, chofunikira pakupanga atherosclerosis, komanso magawo osiyanasiyana a Urolithin A. Ofufuzawa adapeza kuti Urolithin A idaletsa nitric oxide synthase ndikuchepetsa I-CAM, zomwe zidapangitsa kuchepa kwa kutupa ndi kuchepa kwa maselo, makamaka ma monocyte kutsatira ma cell endothelial, motsatana. Kuchepetsa kutsatira monocytic kumachepetsa kutha kwa endothelial.

Komanso, Urolithin A anapezeka kuti amachepetsa kufotokozera kwa chotupa necrosis factor α, interleukin 6, ndi endothelin 1; ma cytokines onse opatsirana.

3. Zotsatira za ma Fibroblasts ku Colon
Colon imakumana ndi tizilombo toyambitsa matenda komanso zakudya zomwe zimapangitsa kuti zikhale zotupa, zomwe pamapeto pake zimatha kubweretsa zovuta zingapo. Monga Urolithin A ndi Urolithin B amapangidwa ndi maluwa am'mimba, ndikofunikira kudziwa momwe zimayambira mthupi momwe amapangidwira.

Kuti aphunzire zotsatira za ma Urolithins pama cell a colon ndi ma fibroblast, ofufuza adachita zoyeserera pomwe ma fibroblast adapezeka ndi ma cytokines omwe amatulutsa zotupa kenako ku Urolithins. Monga tafotokozera pamwambapa, zidapezeka kuti Urolithins imaletsa kumamatira kwa monocyte komanso kusuntha kwa fibroblast kuti muchepetse kutupa m'matumbo.

Kuphatikiza apo, zidapezeka kuti Urolithins amaletsa kuyambitsa kwa NF-κB factor, yomwe ndikofunikira pakuwongolera kutupa. M'malo mwake, ofufuza amakhulupirira kuti ichi ndiye chomwe chimayambitsa anti-yotupa ya ma urolithins.

● Katundu Wotsutsana ndi Khansa
Urolithins amalumikizidwa ndi anti-khansa, ndipo momwe zimapangidwira zimatchulidwa pamwambapa. Komabe, zabwino za malowa zatchulidwa pansipa:

1. Kuteteza ku Cancer ya Prostate
Kudziwika kwa Urolithins m'thupi nthawi zambiri kumachitika pogwiritsa ntchito magazi kapena mkodzo; Komabe, amatha kupezeka m'matumbo mwa amuna ndi akazi komanso prostate gland ya amuna.

Chifukwa cha izi, ofufuza adayesa kuyesa kuti awone ngati maubwino am'madzi akuwoneka mu prostate gland monga momwe ziliri m'matumbo. Chifukwa chake, kafukufuku adapangidwa, zomwe zotsatira zake zimatsimikizira kuti Urolithins amateteza ku prostate gland.

Zinapezeka kuti Urolithin A ndi Urolithin B, limodzi ndi Urolithin C ndi Urolithin D adaletsa michere ya CYP1B1 mu prostate gland. Enzyme imeneyi ndiye cholinga cha chemotherapy ndipo idaletsedwa mwamphamvu ndi Urolithin A, poyerekeza ndi ma urolithin ena. Analetsanso CYP1A1, komabe, urolithins ambiri amafunikira kuti apange izi.

Kafukufuku wina adachitidwa kuti aphunzire zoteteza prostate za Urolithins. Zinapezeka kuti Urolithin A anali ndi anti-cancer ya khansa ya prostate kudzera mwa onse, p53 wodalira komanso p53 m'njira yodziyimira payokha.

2.Topoisomerase 2 ndi CK 2 choletsa
Urolithins ali ndi zida zotsutsana ndi khansa kudzera mu kulepheretsa njira zingapo zamagulu zomwe zimayambitsa kufalikira kwa khansa. Enzyme ya CK2 ndi enzyme yofunikira yomwe imatenga nawo mbali munjira zam'magulu, zomwe ntchito yake yayikulu ndikulimbikitsa kutupa ndi khansa.

Urolithins amaletsa njira zosiyanasiyana kuti afikire enzyme yopezeka paliponse, CK2 kuti ithetse mphamvu yake, monga zida zake zolimbikitsa khansa. Urolithin A yawonetsedwa kuti ndi CK2 inhibitor yamphamvu, ku silico.

Momwemonso, Topoisomerase 2 choletsa amakhulupirira kuti ali ndi zotsatira zotsutsana ndi khansa. M'malo mwake, makinawa amagwiritsa ntchito mankhwala ena monga Doxorubicin. Pakufufuza kwaposachedwa, zidapezeka kuti Urolithin A ndiyamphamvu kwambiri kuposa Doxorubicin poletsa Topoisomerase 2, chifukwa chake, kuyitanitsa kuti iwonjezeredwe pazitsogozo zapano zochizira khansa zina.

● Katundu wa Antibacterial
Ma antibacterial a Urolithins amadalira Quorum Sensing Inhibition yomwe imachotsa kuthekera kwa tizilombo kulumikizana, kusuntha, ndikupanga zinthu zoyipa. Ndi njira yofunikira yopulumutsira mabakiteriya, ndipo kuletsa kwake kwa Urolithins ndikowopsa kwa tizilombo.

Katundu wamkulu wa antibacterial wa Urolithin ndikumatha kuteteza m'matumbo kuchokera ku kuchuluka kwa Yersinia enterocolitica. M'malo mwake, Urolithins amalumikizidwa ndi kusinthasintha kwa maluwa am'matumbo, zomera zomwezo zomwe zimayambitsa kupanga kwawo koyambirira. Izi ndizofunikira makamaka chifukwa zamoyo zokha m'maluwa zimatha kukulitsa Urolithins.

● Katundu wa Anti Estrogenic ndi Estrogenic
Urolithins amamangiriza kuzilandira za Estrogen ndikupanga zonse, estrogenic ndi anti-estrogenic. Izi zimapangitsa kuti akhale woyenera kwambiri pa Selective Estrogen Receptor Modulators kapena ma SERM, njira yayikulu yomwe ingakhalire ndi gawo limodzi mthupi ndikuletsa gawo lina la thupi.

M'modzi mwa maphunziro omwe adachitika chifukwa cha ma urolithins pama estrogen receptors, zidapezeka kuti iwo, makamaka urolithin A, amaletsa kufotokozera kwa ma cell a ER-positive endometrial cell, zomwe zimapangitsa kuti khansa ya endometrial iwonongeke. Endometrial hypertrophy ndi gawo limodzi lodziwika bwino la estrogen potsatira neoplasia ngati amayi omwe amamwa mankhwala obwezeretsa mahomoni, ndipo kugwiritsa ntchito ma urolithins amakhulupirira kuti amateteza ku endometrium. Komabe, kufufuza kwina kuyenera kuchitidwa Urolithins asanakhale mankhwala otsatira a SERM.

● Mapuloteni Glycation Inhibition
Kupezeka kwa zinthu zotsogola kumapeto kwa glycation ndichizindikiro cha hyperglycemia yomwe imapangitsa kuti anthu azidwala matenda ashuga okhudzana ndi mtima kapena matenda a Alzheimer's. Urolithin A ndi Urolithin B awonetsedwa kuti ali ndi mphamvu yotsutsana ndi glycation yomwe imalepheretsa kunyoza mtima ndikuchepetsa chiopsezo cha neurodegeneration kwambiri.

Chifukwa chake, kuletsa kwa protein glycation ndi Urolithins amakhulupirira kuti kumakhala ndi zotsatira za mtima komanso zoteteza ku ubongo.

Ubwino wa Urolithin A watchulidwa pansipa:

● Wonjezerani moyo wautali
Kukalamba, kupsinjika, ndi zovuta zina zitha kuwononga mitochondria, yomwe ndiyofunikira pakupanga mphamvu ndikugwiritsa ntchito thupi. Kuphatikiza apo, mitochondria nthawi zambiri amatchedwa 'mphamvu yama cell', zomwe zikutanthauza kufunikira kwake kwa kugwira ntchito kwa selo. Chifukwa chake, kuwonongeka konse kwa nyumba yamagetsi iyi kumatha kusokoneza cell ndikuchepetsa moyo wake.

Urolithins amachititsa chidwi chomwe chimadziwika kuti mitophagy chomwe chimalola kuti thupi lichotse mitochondria yowonongeka, mosasamala kanthu za kuwonongeka, ndikuwonjezera nthawi ya moyo. Kutengera kuchuluka kwa kuwonongeka, mitochondria itha kubwerezedwanso kuti ipangitse michere komanso kupanga mphamvu.

● Kuteteza ubongo
Monga tafotokozera pamwambapa, ma urolithin ali ndi zotsutsana ndi zotupa ndipo ndi izi zomwe zimalimbikitsa ma cell a neuronal muubongo, zomwe zimathandizira kuzindikira komanso kukumbukira kukumbukira. Kuphatikiza apo, Urolithin A amateteza ku neurodegeneration yomwe imawoneka ndi matenda a Alzheimer's, chifukwa chake, zotsatira za neuroprotective.

● Pewani Khansa ya Prostate
Urolithin A ali ndi zida zotsutsana ndi khansa koma amawoneka makamaka ngati ali ndi khansa ya prostate, pomwe kafukufuku angapo amalimbikitsa kugwiritsa ntchito makangaza ndi magwero ena a Urolithins pochiza khansa ya Prostate.

● Chitani Chonenepetsa
Urolithin A imakhala ndi zotsutsana ndi kunenepa kwambiri chifukwa zimalepheretsa kusungunuka kwamafuta amthupi mthupi komanso zimalepheretsa zolembera zomwe zimayambitsa adipogenesis. Pakafukufuku wopangidwa ndi mitundu yazinyama, zidapezeka kuti Urolithin A imakweza kwambiri mahomoni a chithokomiro a T3, zomwe zimapangitsa kuchuluka kwamagetsi mu mbewa. Izi zimapangitsa kuti thermogenesis ipangike ndipo imayambitsa mafuta ofiira osungunuka, pomwe mafuta oyera amapangidwa kukhala browning.

Pakafukufuku womwewo, zidapezeka kuti URolithin A imathandizira kupewa kunenepa kwambiri ngakhale mbewa zomwe zimadyetsedwa mafuta ambiri. Izi zikuwonetsa lonjezo lalikulu pankhani ya kunenepa kwambiri ndipo ofufuzawa apempha kuti anthu agwiritse ntchito zomwe apezazi kuti athe kugwiritsa ntchito mankhwalawa polimbana ndi mliri wa kunenepa kwambiri.

Ubwino wa Urolithin B ndi awa pansipa:

● Pewani kutayika kwa minofu
Urolithin B amagawana zabwino za Urolithin A koma ali ndi phindu limodzi, losiyana ndi lokha. Urolithin B amadziwika kuti amateteza kutayika kwa minofu m'magulu onse azikhalidwe ndi zamatenda. Kuphatikiza apo, imathandizira kukula kwa mafupa ndikukula kwa mapuloteni m'minyewa.

Zimathandizanso kupewa kupwetekedwa kwa minofu monga tawonera mu kafukufuku wopangidwa ndi mbewa zomwe zidasweka mitsempha yawo. Izi zikadapangitsa kuti minofu iwonongeke koma mbewa zidakonzedwa ndi ma osmotic pump omwe amapitiliza kuwapatsa Urolithin B. Zidapezeka kuti mbewa izi zidaponderezedwa, zomwe zidapangitsa kuti pakhale kusowa kwa minofu ngakhale kuli ndi mitsempha yayikulu. .

Mlingo wa Urolithins

Urolithins amachokera ku zinthu zachilengedwe ndipo zowonjezerazo zimawoneka kuti ndizololedwa bwino popanda wolemba nkhani za poizoni. Komabe, ndikofunikira kukumbukira kuti mankhwalawa akadali pansi pa kafukufuku ndipo ali ndi malire omwe amayenera kutsatiridwa mosamalitsa.

● Urolithin A
Pambuyo pofufuza mozama za maubwino a Urolithin A, panali maphunziro angapo ofufuza omwe adayesa mulingo woyenera wa mankhwalawa. Kafukufuku wa Absorption, Digestion, Metabolism, ndi Elimination adachitidwa kuti aunike zomwe zili mgululi.

Kafukufukuyu adagawika magawo awiri, kutengera kuchuluka kwa masiku, ndipo zidapezeka kuti kafukufukuyu wamasiku 28 ndi 0, 0.175, 1.75, ndi 5.0% a Urolithin A osakanikirana ndi zakudya komanso masiku 90 akuphunzira ndi 0, 1.25, 2.5, ndi 5.0% Urolithin A osakanikirana ndi zakudya sizinasinthe kusintha kwamankhwala, magazi, kapena hematology, ndipo sizinatanthauze njira zilizonse zowopsa. Maphunziro onsewa adayesedwa kwambiri pa 5% UA kulemera kwake pazakudya zomwe zidadzetsa milingo yotsatirayi; 3451 mg / kg BW / tsiku mwa amuna ndi 3826 mg / kg BW / tsiku mwa akazi mu kuphunzira kwamlomo kwa masiku 90.

● Urolithin B
Mofananamo ndi Urolithin A, Urolithin B adaphunziridwa kwambiri kuti awone mulingo woyenera. Ngakhale ndikofunikira kudziwa kuti maphunzirowa amayang'ana pa mlingo woyenera kuti akwaniritse bwino minofu. Mlingowu unapezeka kuti ndi 15uM, kwa amuna ndi akazi onse, mosasamala kanthu za kulemera kwake.

● Urolithin A 8-Methyl Ether
Chigawochi chimagwiritsidwanso ntchito, makamaka chifukwa chimakhala chapakatikati panthawi yopanga Urolithin A. Komabe, sikunafufuzidwe kokwanira komwe kwachitika kuti pakhale mlingo woyenera wa Urolithin.

Zakudya Zakudya za Urolithins

Ma Urolithin sapezeka mwachilengedwe kulikonse komwe mungapeze chakudya, komabe, amapezeka ngati ellagitannins. Matanniniwa amasanduka ellagic acid, omwe amapangitsanso Urolithin A 8-Methyl ether, kenako ku Urolithin A, ndipo pamapeto pake, Urolithin B. Zakudya zomwe zili ndi Urolithins ndi izi:

ZakudyaEllagic Acid
Zipatso (mg / 100g kulemera kwatsopano)
Mabulosi akuda150
Mabulosi akuda akuda90
Achimwene70
Mawonekedwe a mtambo315.1
makangaza> 269.9
Ma rasipiberi270
Ananyamuka m'chiuno109.6
Froberries77.6
Kupanikizana Strawberry24.5
Raspberries wachikasu1900
Mtedza (mg / g)
mtedza33
Walnuts59
Zakumwa (mg / L)
Madzi a makangaza811.1
Mowa wamphesa31-55
Vinyo wofiira wazaka zambiri33
Whisky1.2
Mbewu (mg / g)
Mabulosi akuda akuda6.7
Ma rasipiberi ofiira8.7
Achimwene30
wamango1.2


Monga tawonera patebulo, Cloudberries ndi chipatso chokhala ndi Ellagitannins kwambiri ndi Ellagic acid, pomwe Makangaza ali pafupi kwambiri. Madzi a makangaza, komabe, ndi gwero lamphamvu kwambiri, pafupifupi katatu mwamphamvu ngati Cloudberries.

Ndikofunikira kudziwa kuti zomwe zili ndi ellagic acid pazakudya sizikhala zofanana ndi urolithin mthupi. Kupezeka kwa ma URolithins kumadalira kwambiri matumbo a microbiota a munthu aliyense.

Chifukwa Chiyani Muyenera Kugula Kuchokera Kampani Yathu Yopanga?

Urolithin Powder A ndi Urolithin Powder B akupezeka ambiri, ku fakitale yathu yopanga yomwe imaphatikizira kupanga, kufufuza, chitukuko, ndi kugulitsa zowonjezera. Zogulitsa zathu zimapangidwa molondola kwambiri kutsatira ndondomeko zonse zachitetezo, zomwe zimatsimikizira kuti chitetezo chomaliza ndichabwino kwambiri. Zogulitsa zonse zimafufuzidwa zisanapangidwe ndipo zimayesedwa bwino panthawi yopanga ndi pambuyo pake kuti zikwaniritse miyezo yanu yabwino.

Pambuyo popanga, zinthu zimayesedwa kumalabu athu nthawi ina kuti tifufuze za potency, potency, ndi chitetezo cha Urolithin ufa ndi zinthu zina. Zikakonzeka kugawidwa, zogulitsazo zimadzazidwa ndikusungidwa m'malo oyenera, kutentha koyenera ndikutsatira malangizo onse kuti mutsimikizire kuti malonda apamwamba amakufikirani. Urolithin ufa samawunikiridwa ndi dzuwa mukamanyamula, kulongedza, kapena kusungira monga momwe zingawononge zomalizira.

Kugula Urolithin A ufa ndi Urolithin B ufa kuchokera ku fakitale yathu yopanga kumatsimikizira chinthu chapamwamba kwambiri pamitengo yotsika mtengo kwambiri.

Tsamba:

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  3. Juan Carlos Espín, Mar Larrosa, María Teresa García-Conesa, Francisco Tomás-Barberán, "Biological Significance of Urolithins, the Gut Microbial Ellagic Acid-Derives Metabolites: The Evidence So Far", Umboni Wothandizidwa ndi Umboni Wothandizirana ndi Njira Zina, vol. 2013, Article ID 270418, masamba 15, 2013. https://doi.org/10.1155/2013/270418.
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